A meta-analysis of the bradykinin B2 receptor gene --58C/T polymorphism with hypertension

Clin Chim Acta. 2010 Mar;411(5-6):324-8. doi: 10.1016/j.cca.2009.12.015. Epub 2009 Dec 28.

Abstract

Background and objective: Numerous studies have attempted to associate -58C/T polymorphism of bradykinin B2 receptor gene (BDKRB2) with hypertension, whereas results were often irreproducible. We performed a meta-analysis aiming to provide a comprehensive evaluation of this polymorphism and hypertension.

Methods: Case-control reports published in English were searched totaling four studies with six populations (823 cases and 916 controls). Random-effects model was applied irrespective of between-study heterogeneity, and study quality was assessed in duplicate.

Results: Compared with -58C allele carriers, those with -58T allele had a lower yet nonsignificant risk for hypertension (OR=0.86; 95% CI: 0.68-1.09; P=0.21). Lack of significance persisted after combining those with genotypes -58TC and -58TT together (OR=0.87; 95% CI: 0.67-1.09; P=0.21) or with -58TC and -58CC together (OR=0.75; 95% CI: 0.48-1.18; P=0.22) in association with hypertension. Sensitivity analyses by race indicated that comparison of -58T versus -58C generated a protective effect for hypertension in Asians (OR=0.77; 95% CI: 0.58-1.02; P=0.07) and African-Americans (OR=0.65; 95% CI: 0.43-0.98; P=0.04), but a risk effect in Caucasians (OR=1.22; 95% CI: 0.92-1.61; P=0.17). No publication bias was observed.

Conclusions: Our results suggested that -58T allele exhibited a protective effect on hypertension in Asians and African-Americans, yet a risk effect in Caucasians.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Humans
  • Hypertension / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Racial Groups / genetics
  • Receptor, Bradykinin B2 / genetics*

Substances

  • Receptor, Bradykinin B2