This is a Validated Antibody Database (VAD) review about human DRD2, based on 29 published articles (read how Labome selects the articles), using DRD2 antibody in all methods. It is aimed to help Labome visitors find the most suited DRD2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DRD2 synonym: D2DR; D2R; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor

Knockout validation
EMD Millipore
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2e
  • western blot knockout validation; mouse; 1:250; loading ...; fig 1c
EMD Millipore DRD2 antibody (Merck Millipore, AB5084P) was used in immunohistochemistry knockout validation on mouse samples at 1:50 (fig 2e) and in western blot knockout validation on mouse samples at 1:250 (fig 1c). Amino Acids (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-10)
  • immunocytochemistry; mouse; loading ...; fig 5b
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in immunocytochemistry on mouse samples (fig 5b). Neuropharmacology (2016) ncbi
mouse monoclonal (B-10)
  • immunohistochemistry - paraffin section; rat; fig 5
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in immunohistochemistry - paraffin section on rat samples (fig 5). Psychopharmacology (Berl) (2016) ncbi
mouse monoclonal (B-10)
  • western blot; mouse; 1:20; fig 2
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in western blot on mouse samples at 1:20 (fig 2). Transl Psychiatry (2016) ncbi
mouse monoclonal (B-10)
  • immunohistochemistry - paraffin section; human; 1:50; fig 6
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 6). J Neuroimmune Pharmacol (2016) ncbi
mouse monoclonal (B-10)
  • immunohistochemistry - paraffin section; mouse; 1:100
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc5303) was used in immunohistochemistry - paraffin section on mouse samples at 1:100. PLoS Genet (2014) ncbi
mouse monoclonal (B-10)
  • immunohistochemistry; rabbit; 1:100
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz Biotechnology, sc-5303) was used in immunohistochemistry on rabbit samples at 1:100. PLoS ONE (2014) ncbi
mouse monoclonal (B-10)
  • western blot; mouse; 1:200
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in western blot on mouse samples at 1:200. J Huntingtons Dis (2012) ncbi
mouse monoclonal (B-10)
  • western blot; mouse; 1:200; fig 4
Santa Cruz Biotechnology DRD2 antibody (Santa Cruz, sc-5303) was used in western blot on mouse samples at 1:200 (fig 4). PLoS ONE (2010) ncbi
EMD Millipore
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2e
  • western blot knockout validation; mouse; 1:250; loading ...; fig 1c
EMD Millipore DRD2 antibody (Merck Millipore, AB5084P) was used in immunohistochemistry knockout validation on mouse samples at 1:50 (fig 2e) and in western blot knockout validation on mouse samples at 1:250 (fig 1c). Amino Acids (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig s5a
EMD Millipore DRD2 antibody (Milipore, AB5084P) was used in western blot on mouse samples at 1:1000 (fig s5a). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; rat; loading ...; fig 5c
In order to examine the effects of dietary calcium supplementation and the mesocorticolimbic dopaminergic reward system in obese rats, EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples (fig 5c). J Neuroendocrinol (2016) ncbi
rabbit polyclonal
  • western blot; rat; 1:500; loading ...; fig 2
EMD Millipore DRD2 antibody (Calbiochem, AB508P) was used in western blot on rat samples at 1:500 (fig 2). Dev Neurobiol (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:750; fig s4
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in immunocytochemistry on human samples at 1:750 (fig s4). Eur Neuropsychopharmacol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on mouse samples at 1:1000. J Neurosci Res (2015) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:1000. Neuropsychopharmacology (2016) ncbi
rabbit polyclonal
  • western blot; rat; 1:500
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:500. Addict Biol (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:300
EMD Millipore DRD2 antibody (Chemicon, AB5084P) was used in immunohistochemistry - frozen section on mouse samples at 1:300. Behav Brain Res (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; rat; 2 ug/ml
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in immunohistochemistry - frozen section on rat samples at 2 ug/ml. Eur J Histochem (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
In order to investigate the effect of early postnatal overfeeding on insulin signaling in the ventral tegmental area, EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:1000. Behav Brain Res (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; rat; 1:200
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in immunohistochemistry - frozen section on rat samples at 1:200. BMC Complement Altern Med (2014) ncbi
rabbit polyclonal
  • western blot; rat
In order to examine the p.G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) and it's role in Parkinson's disease, EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples . J Parkinsons Dis (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:1000. PLoS ONE (2014) ncbi
rabbit polyclonal
  • immunoprecipitation; rat; 1:1000
  • western blot; rat; 1:1000
EMD Millipore DRD2 antibody (EDM Millipore, AB5084P) was used in immunoprecipitation on rat samples at 1:1000 and in western blot on rat samples at 1:1000. Int J Mol Sci (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:500
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:500. Mol Pain (2013) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in western blot on rat samples at 1:1000. Addict Biol (2014) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:5000
EMD Millipore DRD2 antibody (Chemicon International, AB5084P) was used in immunohistochemistry on mouse samples at 1:5000. Neuroscience (2013) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse
EMD Millipore DRD2 antibody (Chemicon, AB5084P) was used in immunohistochemistry - paraffin section on mouse samples . PLoS ONE (2013) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:200; fig 2
EMD Millipore DRD2 antibody (Millipore, AB5084P) was used in immunocytochemistry on human samples at 1:200 (fig 2). Stem Cell Rev (2013) ncbi
rabbit polyclonal
  • western blot; human; 1:300
EMD Millipore DRD2 antibody (Chemicon, AB5084P) was used in western blot on human samples at 1:300. Stem Cells Dev (2013) ncbi
Articles Reviewed
  1. Stojanovic T, Orlova M, Sialana F, Höger H, Stuchlík S, Milenkovic I, et al. Validation of dopamine receptor DRD1 and DRD2 antibodies using receptor deficient mice. Amino Acids. 2017;49:1101-1109 pubmed publisher
  2. Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
  3. Luessen D, Hinshaw T, Sun H, Howlett A, MARRS G, McCool B, et al. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016;110:297-307 pubmed publisher
  4. Listos J, Baranowska Bosiacka I, Wasik A, Talarek S, Tarnowski M, Listos P, et al. The adenosinergic system is involved in sensitization to morphine withdrawal signs in rats-neurochemical and molecular basis in dopaminergic system. Psychopharmacology (Berl). 2016;233:2383-97 pubmed publisher
  5. Conceição E, Carvalho J, Manhães A, Guarda D, Figueiredo M, Quitete F, et al. Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation. J Neuroendocrinol. 2016;28: pubmed publisher
  6. Lauretti E, Di Meco A, Merali S, Praticò D. Chronic behavioral stress exaggerates motor deficit and neuroinflammation in the MPTP mouse model of Parkinson's disease. Transl Psychiatry. 2016;6:e733 pubmed publisher
  7. Buzhdygan T, Lisinicchia J, Patel V, Johnson K, Neugebauer V, Paessler S, et al. Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection. J Neuroimmune Pharmacol. 2016;11:279-93 pubmed publisher
  8. Romano López A, Méndez Díaz M, García F, Regalado Santiago C, Ruiz Contreras A, Prospero Garcia O. Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats. Dev Neurobiol. 2016;76:819-31 pubmed publisher
  9. Harmeier A, Obermueller S, Meyer C, Revel F, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharmacol. 2015;25:2049-61 pubmed publisher
  10. Pflibsen L, Stang K, Sconce M, Wilson V, Hood R, Meshul C, et al. Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2015;93:1849-64 pubmed publisher
  11. Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016;41:811-21 pubmed publisher
  12. García Pérez D, Núñez C, Laorden M, Milanés M. Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal. Addict Biol. 2016;21:374-86 pubmed publisher
  13. Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed publisher
  14. Yokoi F, Dang M, Liu J, Gandre J, Kwon K, Yuen R, et al. Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice. Behav Brain Res. 2015;279:202-10 pubmed publisher
  15. Romero Fernandez W, Borroto Escuela D, Vargas Barroso V, Narváez M, Di Palma M, Agnati L, et al. Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons. Eur J Histochem. 2014;58:2400 pubmed publisher
  16. Portella A, Silveira P, Laureano D, Cardoso S, Bittencourt V, Noschang C, et al. Litter size reduction alters insulin signaling in the ventral tegmental area and influences dopamine-related behaviors in adult rats. Behav Brain Res. 2015;278:66-73 pubmed publisher
  17. Parillo F, Maranesi M, Mignini F, Marinelli L, Di Stefano A, Boiti C, et al. Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea. PLoS ONE. 2014;9:e104797 pubmed publisher
  18. Gao J, Tu S, Liu J, Zhang J, Huang Y, Han M, et al. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats. BMC Complement Altern Med. 2014;14:308 pubmed publisher
  19. Walker M, Volta M, Cataldi S, Dinelle K, Beccano Kelly D, Munsie L, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. J Parkinsons Dis. 2014;4:483-98 pubmed publisher
  20. Lotan D, Cunningham M, Joel D. Antibiotic treatment attenuates behavioral and neurochemical changes induced by exposure of rats to group a streptococcal antigen. PLoS ONE. 2014;9:e101257 pubmed publisher
  21. Chauhan H, Killinger B, Miller C, Moszczynska A. Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. Int J Mol Sci. 2014;15:5884-906 pubmed publisher
  22. Galbavy W, Safaie E, Rebecchi M, Puopolo M. Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors. Mol Pain. 2013;9:60 pubmed publisher
  23. O Dell L, Natividad L, Pipkin J, Roman F, Torres I, Jurado J, et al. Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol. 2014;19:1006-19 pubmed publisher
  24. Neve K, Ford C, Buck D, Grandy D, Neve R, Phillips T. Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S. Neuroscience. 2013;248:479-87 pubmed publisher
  25. Giesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, et al. Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice. PLoS ONE. 2013;8:e63778 pubmed publisher
  26. Delli Carri A, Onorati M, Castiglioni V, Faedo A, Camnasio S, Toselli M, et al. Human pluripotent stem cell differentiation into authentic striatal projection neurons. Stem Cell Rev. 2013;9:461-74 pubmed publisher
  27. Sarantos M, Papanikolaou T, Ellerby L, Hughes R. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. J Huntingtons Dis. 2012;1:195-210 pubmed publisher
  28. Belinsky G, Sirois C, Rich M, Short S, Moore A, Gilbert S, et al. Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev. 2013;22:1522-40 pubmed publisher
  29. Kurz A, Double K, Lastres Becker I, Tozzi A, Tantucci M, Bockhart V, et al. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS ONE. 2010;5:e11464 pubmed publisher