product summary
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company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Dystrophin antibody
catalog :
ab15277
quantity :
1 ml
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, dogs, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 52
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:200; loading ...; fig 3a
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1g
Li Y, Zhang Y, Hu Q, Egranov S, Xing Z, Zhang Z, et al. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021;13:137 pubmed publisher
  • western blot; pigs ; 1:400; loading ...; fig 2e
Zou X, Ouyang H, Pang D, Han R, Tang X. Pathological alterations in the gastrointestinal tract of a porcine model of DMD. Cell Biosci. 2021;11:131 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 1b
Fujiwara D, Iwahara N, Sebori R, Hosoda R, Shimohama S, Kuno A, et al. SIRT1 deficiency interferes with membrane resealing after cell membrane injury. PLoS ONE. 2019;14:e0218329 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5c
Rubio Fernández M, Uribe M, Vicente Tejedor J, Germain F, Susín Lara C, Quereda C, et al. Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy. Sci Rep. 2018;8:8543 pubmed publisher
  • western blot; human; fig 3d
Long C, Li H, Tiburcy M, Rodriguez Caycedo C, Kyrychenko V, Zhou H, et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018;4:eaap9004 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 4g
Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2a
Guiraud S, Migeon T, Ferry A, Chen Z, Ouchelouche S, Verpont M, et al. HANAC Col4a1 Mutation in Mice Leads to Skeletal Muscle Alterations due to a Primary Vascular Defect. Am J Pathol. 2017;187:505-516 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 9
Southard S, Kim J, Low S, Tsika R, Lepper C. Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency. elife. 2016;5: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 6
Vanhoutte D, Schips T, Kwong J, Davis J, Tjondrokoesoemo A, Brody M, et al. Thrombospondin expression in myofibers stabilizes muscle membranes. elife. 2016;5: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5a
Egner I, Bruusgaard J, Gundersen K. Satellite cell depletion prevents fiber hypertrophy in skeletal muscle. Development. 2016;143:2898-906 pubmed publisher
  • western blot; dogs; 1:1000; fig s1h
Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 7
  • immunocytochemistry; human; fig 4
Park S, Choi Y, Jung N, Yu Y, Ryu K, Kim H, et al. Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. Int J Mol Med. 2016;37:1209-20 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 5
  • western blot; human; fig 5
Maggio I, Stefanucci L, Janssen J, Liu J, Chen X, Mouly V, et al. Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations. Nucleic Acids Res. 2016;44:1449-70 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 5
Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent M, Molkentin J. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet. 2016;25:1192-202 pubmed publisher
  • immunohistochemistry - frozen section; human
Nilsen T, Thorsen L, Fosså S, Wiig M, Kirkegaard C, Skovlund E, et al. Effects of strength training on muscle cellular outcomes in prostate cancer patients on androgen deprivation therapy. Scand J Med Sci Sports. 2016;26:1026-35 pubmed publisher
Wang C, Rabadan Ros R, Martínez Redondo P, Ma Z, Shi L, Xue Y, et al. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nat Commun. 2021;12:3094 pubmed publisher
Yin Z, Lin J, Yan R, Liu R, Liu M, Zhou B, et al. Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture. Adv Sci (Weinh). 2020;7:2000938 pubmed publisher
Nogami K, Maruyama Y, Elhussieny A, Sakai Takemura F, Tanihata J, Kira J, et al. iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin. BMC Musculoskelet Disord. 2020;21:479 pubmed publisher
Maggio I, Zittersteijn H, Wang Q, Liu J, Janssen J, Ojeda I, et al. Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components. Gene Ther. 2020;27:209-225 pubmed publisher
Morisaka H, Yoshimi K, Okuzaki Y, Gee P, Kunihiro Y, Sonpho E, et al. CRISPR-Cas3 induces broad and unidirectional genome editing in human cells. Nat Commun. 2019;10:5302 pubmed publisher
Sato T, Higashioka K, Sakurai H, Yamamoto T, Goshima N, Ueno M, et al. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports. 2019;13:352-365 pubmed publisher
Wang C, Arrington J, Ratliff A, Chen J, Horton H, Nie Y, et al. Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice. J Biol Chem. 2019;294:13718-13728 pubmed publisher
Egorova T, Zotova E, Reshetov D, Polikarpova A, Vassilieva S, Vlodavets D, et al. CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene. Dis Model Mech. 2019;12: pubmed publisher
Ooi J, Langley S, Xu X, Utami K, Sim B, Huang Y, et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects. Cell Rep. 2019;26:2494-2508.e7 pubmed publisher
Jelínková S, Fojtik P, Kohutova A, Vilotic A, Markova L, Pesl M, et al. Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress. Cells. 2019;8: pubmed publisher
Maani N, Sabha N, Rezai K, Ramani A, Groom L, Eltayeb N, et al. Tamoxifen therapy in a murine model of myotubular myopathy. Nat Commun. 2018;9:4849 pubmed publisher
Smith T, Saul R, Barton E, Luna E. Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms. PLoS ONE. 2018;13:e0205910 pubmed publisher
Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, et al. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018;560:661-665 pubmed publisher
Viola H, Johnstone V, Adams A, Fletcher S, Hool L. A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy. JACC Basic Transl Sci. 2018;3:391-402 pubmed publisher
Chan S, Arpke R, Filareto A, Xie N, Pappas M, Penaloza J, et al. Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity. Cell Stem Cell. 2018;23:74-85.e6 pubmed publisher
Wang D, Mokhonova E, Kendall G, Becerra D, Naeini Y, Cantor R, et al. Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse. Mol Ther Nucleic Acids. 2018;11:180-191 pubmed publisher
Kawaguchi T, Niba E, Rani A, Onishi Y, Koizumi M, Awano H, et al. Detection of Dystrophin Dp71 in Human Skeletal Muscle Using an Automated Capillary Western Assay System. Int J Mol Sci. 2018;19: pubmed publisher
Xu J, Xu L, Lau Y, Gao Y, Moore S, Han R. A novel ANO5 splicing variant in a LGMD2L patient leads to production of a truncated aggregation-prone Ano5 peptide. J Pathol Clin Res. 2018;4:135-145 pubmed publisher
Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung T, et al. p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. 2018;37: pubmed publisher
Tosic M, Allen A, Willmann D, Lepper C, Kim J, Duteil D, et al. Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells. Nat Commun. 2018;9:366 pubmed publisher
Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N. Engineering human pluripotent stem cells into a functional skeletal muscle tissue. Nat Commun. 2018;9:126 pubmed publisher
Bassat E, Mutlak Y, Genzelinakh A, Shadrin I, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017;547:179-184 pubmed publisher
Niba E, Yamanaka R, Rani A, Awano H, Matsumoto M, Nishio H, et al. DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification. Cancer Cell Int. 2017;17:58 pubmed publisher
Zhang Y, Long C, Li H, McAnally J, Baskin K, Shelton J, et al. CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice. Sci Adv. 2017;3:e1602814 pubmed publisher
Grünberg J, Hoffmann J, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, et al. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017;7:43515 pubmed publisher
Yang X, Yang S, Wang C, Kuang S. The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration. J Biol Chem. 2017;292:5981-5991 pubmed publisher
Goh Q, Millay D. Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy. elife. 2017;6: pubmed publisher
Pryce B, Al Zahrani K, Dufresne S, Belkina N, Labrèche C, Patino Lopez G, et al. Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017;7:3 pubmed publisher
Xu L, Zhao L, Gao Y, Xu J, Han R. Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA. Nucleic Acids Res. 2017;45:e28 pubmed publisher
Yu H, Zhao H, Qing Y, Pan W, Jia B, Zhao H, et al. Porcine Zygote Injection with Cas9/sgRNA Results in DMD-Modified Pig with Muscle Dystrophy. Int J Mol Sci. 2016;17: pubmed
Hendriksen R, Schipper S, Hoogland G, Schijns O, Dings J, Aalbers M, et al. Dystrophin Distribution and Expression in Human and Experimental Temporal Lobe Epilepsy. Front Cell Neurosci. 2016;10:174 pubmed publisher
Baradaran Heravi A, Balgi A, Zimmerman C, Choi K, Shidmoossavee F, Tan J, et al. Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. Nucleic Acids Res. 2016;44:6583-98 pubmed publisher
Vella L, Markworth J, Paulsen G, Raastad T, Peake J, Snow R, et al. Ibuprofen Ingestion Does Not Affect Markers of Post-exercise Muscle Inflammation. Front Physiol. 2016;7:86 pubmed publisher
Vikmoen O, Raastad T, Seynnes O, Bergstrøm K, Ellefsen S, Rønnestad B. Effects of Heavy Strength Training on Running Performance and Determinants of Running Performance in Female Endurance Athletes. PLoS ONE. 2016;11:e0150799 pubmed publisher
Juo L, Liao W, Shih Y, Yang B, Liu A, Yan Y. HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. J Cell Sci. 2016;129:1661-70 pubmed publisher
Garbincius J, Michele D. Dystrophin-glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling. Proc Natl Acad Sci U S A. 2015;112:13663-8 pubmed publisher
Lo Verso F, Carnio S, Vainshtein A, Sandri M. Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity. Autophagy. 2014;10:1883-94 pubmed publisher
product information
CatalogNumber :
ab15277
ItemName :
Anti-Dystrophin antibody
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Not Conjugated
Antigen Modification :
No Modifications
Size :
1 ml
SpeciesSummary :
Dog, Hu, Ms, Rat
Uses :
ICC/IF, IHC - Wmt, IHC-Fr, IHC-P, WB
Size Note :
Other sizes available: 100 µl,500 µl
more info or order :
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK