product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb
catalog :
9664
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
5A1E
reactivity :
African green monkey, human, mouse, rat, dogs, chicken, zebrafish , rhesus macaque, purple urchin
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other
more info or order :
Cell Signaling Technology product webpage
citations: 636
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1500; loading ...; fig 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 7c
  • western blot; human; 1:1000; loading ...; fig 5a
Xu Y, Chen X, Pan S, Wang Z, Zhu X. TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer. Cell Death Discov. 2021;7:299 pubmed publisher
  • western blot; mouse
Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, et al. Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation. Front Physiol. 2021;12:706359 pubmed publisher
  • western blot; mouse; fig 7a
Gao C, Deng J, Zhang H, Li X, Gu S, Zheng M, et al. HSPA13 facilitates NF-κB-mediated transcription and attenuates cell death responses in TNFα signaling. Sci Adv. 2021;7:eabh1756 pubmed publisher
  • western blot; human; loading ...; fig 5g
Lü Z, Liu H, Song N, Liang Y, Zhu J, Chen J, et al. METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1. Cell Death Dis. 2021;12:881 pubmed publisher
  • western blot; mouse; fig 5b
  • western blot; rat; 1:2000; loading ...; fig 1e
Li W, Lin Y, Luo Y, Wang Y, Lu Y, Li Y, et al. Vitamin D Receptor Protects against Radiation-Induced Intestinal Injury in Mice via Inhibition of Intestinal Crypt Stem/Progenitor Cell Apoptosis. Nutrients. 2021;13: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5f
Gahankari A, Dong C, Bartoletti G, Galazo M, He F. Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development. Front Cell Dev Biol. 2021;9:704769 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e, 1h
Xue Y, Morris J, Yang K, Fu Z, Zhu X, Johnson F, et al. SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria. Nat Commun. 2021;12:5404 pubmed publisher
  • western blot; mouse; 1:500; fig 4a
Rossino M, Amato R, Amadio M, Rosini M, Basagni F, Cammalleri M, et al. A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration. Antioxidants (Basel). 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 7e
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson M, Schmitz W, Wach S, et al. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun. 2021;12:5066 pubmed publisher
  • western blot; human; loading ...; fig 4a
Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, et al. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021;12:4928 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 4f
Maurizy C, Abeza C, Lemmers B, Gabola M, Longobardi C, Pinet V, et al. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021;12:4810 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
He Y, Li H, Yao J, Zhong H, Kuang Y, Li X, et al. HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury. Int J Mol Med. 2021;48: pubmed publisher
  • western blot; human; loading ...
Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed publisher
  • western blot; human; fig 2a
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, et al. Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell Rep. 2021;36:109490 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 5b
Oh H, Choi A, Seo N, Lim J, You J, Chung Y. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on post-contrast acute kidney injury. Sci Rep. 2021;11:15625 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1e
Clark A, Kugathasan U, Baskozos G, Priestman D, Fugger N, Lone M, et al. An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med. 2021;2:100345 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig s3b
Shao C, Lou P, Liu R, Bi X, Li G, Yang X, et al. Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland. Front Cell Dev Biol. 2021;9:691050 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5b
Lin X, Wang C, Zhang Q, Pan Y, Dang S, Zhang W. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Reprod Biol. 2021;21:100537 pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Hao L, Zhong W, Sun X, Zhou Z. TLR9 Signaling Protects Alcohol-Induced Hepatic Oxidative Stress but Worsens Liver Inflammation in Mice. Front Pharmacol. 2021;12:709002 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 3a
Beaulac H, Gilels F, Zhang J, Jeoung S, White P. Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice. Cell Death Dis. 2021;12:682 pubmed publisher
  • western blot; human; loading ...; fig 3c
Lee S, Jung J, Lee Y, Kim S, Kim J, Kim B, et al. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; fig 2e
  • immunohistochemistry; mouse; loading ...; fig 2c
  • western blot; mouse; 1:1000; loading ...; fig 2a, 2b
Fisher A, Sangkhae V, Balusikova K, Palaskas N, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021;12:4026 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 9b
Mu X, Tu Z, Chen X, Hong Y, Geng Y, Zhang Y, et al. In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Front Cell Dev Biol. 2021;9:669732 pubmed publisher
  • immunohistochemistry; human; loading ...; fig s6g
  • western blot; human; loading ...; fig 5d
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 8a
Liu C, Chi K, Geng X, Hong Q, Mao Z, Huang Q, et al. Exogenous Biological Renal Support Improves Kidney Function in Mice With Rhabdomyolysis-Induced Acute Kidney Injury. Front Med (Lausanne). 2021;8:655787 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6d
Zhang J, Terán G, Popa M, Madapura H, Ladds M, Lianoudaki D, et al. DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance. iScience. 2021;24:102494 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1c, 5b
Lasierra Losada M, Pauler M, Vandamme N, Goossens S, Berx G, Leppkes M, et al. Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells. Cell Death Discov. 2021;7:138 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1f
  • western blot; mouse; 1:500; loading ...; fig 1c
Yan C, Saleh N, Yang J, Nebhan C, Vilgelm A, Reddy E, et al. Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Mol Cancer. 2021;20:85 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 1h
Wu Y, Xie L, Hua Y, Xu H, Chen G, Han X, et al. Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. Front Pharmacol. 2021;12:644116 pubmed publisher
  • western blot; human; 1:2000; loading ...
Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, et al. Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. J Exp Clin Cancer Res. 2021;40:182 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3d
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 8g
Ma X, Zhao T, Yan H, Guo K, Liu Z, Wei L, et al. Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death Dis. 2021;12:544 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4c
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6b
Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed publisher
  • western blot; human; loading ...; fig 8b
Sun L, Liu S, Wang X, Zheng X, Chen Y, Shen H. eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway. J Transl Med. 2021;19:216 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4g
Filppu P, Tanjore Ramanathan J, Granberg K, Gucciardo E, Haapasalo H, Lehti K, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6: pubmed publisher
  • western blot; mouse; loading ...; fig 4h
Liu Y, Cong P, Zhang T, Wang R, Wang X, Liu J, et al. Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. Redox Biol. 2021;43:102002 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 1g
Liberti D, Kremp M, Liberti W, Penkala I, Li S, Zhou S, et al. Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury. Cell Rep. 2021;35:109092 pubmed publisher
  • western blot; human; loading ...; fig 1a
Liu Y, Xu S, Zhang H, Qian K, Huang J, Gu X, et al. Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis. Cell Death Dis. 2021;12:448 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...; fig 1e
Nasu M, Esumi S, Hatakeyama J, Tamamaki N, Shimamura K. Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Front Cell Dev Biol. 2021;9:632381 pubmed publisher
  • western blot; human; loading ...; fig 4c, 4e
Chen X, Ma W, Yao Y, Zhang Q, Li J, Wu X, et al. Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. Cell Death Dis. 2021;12:425 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Lu H, Hsu H, Li C, Li S, Lin S, Shih C, et al. Hydrogen Sulfide Attenuates Aortic Remodeling in Aortic Dissection Associating with Moderated Inflammation and Oxidative Stress through a NO-Dependent Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 1d
Nakajima W, Miyazaki K, Asano Y, Kubota S, Tanaka N. Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Genes (Basel). 2021;12: pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Li X, Huang K, Liu X, Ruan H, Ma L, Liang J, et al. Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway. Front Pharmacol. 2021;12:639574 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3g
Tian F, Zhang Y. Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering. Front Cell Dev Biol. 2021;9:636553 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 6e
Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021;12:2281 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1f
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12:2259 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1g
Shu H, Guo Z, Chen X, Qi S, Xiong X, Xia S, et al. Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Aging Dis. 2021;12:371-385 pubmed publisher
  • western blot; human; fig 2f
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4g
  • western blot; mouse; loading ...; fig 4h
Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Grandits A, Nguyen C, Schlerka A, Hackl H, Sill H, Etzler J, et al. Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness. Leukemia. 2021;35:2827-2839 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2d
Gu X, Wang D, Xu Z, Wang J, Guo L, Chai R, et al. Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing. Genome Biol. 2021;22:86 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4b
Sewastianik T, Straubhaar J, Zhao J, Samur M, Adler K, Tanton H, et al. miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. Blood. 2021;137:1905-1919 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Liu X, Jiang J, Liao Y, Tang I, Zheng E, Qiu W, et al. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Adv Sci (Weinh). 2021;8:2002147 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...
Wang F, Gervasi M, Boskovic A, Sun F, Rinaldi V, Yu J, et al. Deficient spermiogenesis in mice lacking Rlim. elife. 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3h
Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, et al. Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell Death Dis. 2021;12:72 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2c
Jubair L, Lam A, Fallaha S, McMillan N. CRISPR/Cas9-loaded stealth liposomes effectively cleared established HPV16-driven tumours in syngeneic mice. PLoS ONE. 2021;16:e0223288 pubmed publisher
  • western blot; human; loading ...; fig 3d
Huang H, Yu X, Han X, Hao J, Zhao J, Bebek G, et al. Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression. Cell Rep. 2021;34:108522 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 1d
Atkins A, Xu M, Li M, Rogers N, Pryzhkova M, Jordan P. SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...
Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6e
Cai J, Lin K, Cai W, Lin Y, Liu X, Guo L, et al. Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1. Mol Oncol. 2020;14:3153-3168 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3s1a
Hasenpusch Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, et al. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...
Chen T, Lennon V, Liu Y, Bosco D, Li Y, Yi M, et al. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. J Clin Invest. 2020;130:4025-4038 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 5h
Hernández I, Cabrera J, Santos Galindo M, Sanchez Martin M, Dominguez V, García Escudero R, et al. Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Brain. 2020;143:2207-2219 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig e8f
Kyprianou C, Christodoulou N, Hamilton R, Nahaboo W, Boomgaard D, Amadei G, et al. Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020;582:253-258 pubmed publisher
  • western blot; human; 1:250; loading ...; fig 5f
Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk S. MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7h
Nava M, Miroshnikova Y, Biggs L, Whitefield D, Metge F, Boucas J, et al. Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020;181:800-817.e22 pubmed publisher
  • western blot; mouse; 1:1000; fig 2i
Li M, Li C, Ye Z, Huang J, Li Y, Lai W, et al. Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. J Cell Mol Med. 2020;24:5109-5121 pubmed publisher
  • western blot; mouse; 1:750; loading ...; fig 7a
Zhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3g
Ruscetti M, Morris J, Mezzadra R, Russell J, Leibold J, Romesser P, et al. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020;181:424-441.e21 pubmed publisher
  • western blot; human; loading ...; fig 3d
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s3h
Mukhtar T, Breda J, Grison A, Karimaddini Z, Grobecker P, Iber D, et al. Tead transcription factors differentially regulate cortical development. Sci Rep. 2020;10:4625 pubmed publisher
  • western blot; human; loading ...; fig 2b
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4c
  • western blot; mouse; loading ...; fig 2b, 4b
Wang Bishop L, Wehbe M, Shae D, James J, Hacker B, Garland K, et al. Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. J Immunother Cancer. 2020;8: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7e
Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1f
Chappell G, Thompson C, Wolf J, Cullen J, Klaunig J, Haws L. Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicol Pathol. 2020;48:494-508 pubmed publisher
  • western blot; human; loading ...; fig 2e
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Chen Y, Liu Z, Wang Y, Zhuang J, Peng Y, Mo X, et al. FKBP51 induces p53-dependent apoptosis and enhances drug sensitivity of human non-small-cell lung cancer cells. Exp Ther Med. 2020;19:2236-2242 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig 5a
  • western blot; mouse; 1:1000; loading ...; fig 5d
Duan X, Liu X, Liu N, Huang Y, Jin Z, Zhang S, et al. Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. Cell Death Dis. 2020;11:134 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig s4
Ebright R, Lee S, Wittner B, Niederhoffer K, Nicholson B, Bardia A, et al. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science. 2020;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y. Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development. Sci Rep. 2020;10:1884 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1e
Markotic A, Flegar D, Grcevic D, Sućur A, Lalić H, Turcić P, et al. LPS-induced inflammation desensitizes hepatocytes to Fas-induced apoptosis through Stat3 activation-The effect can be reversed by ruxolitinib. J Cell Mol Med. 2020;24:2981-2992 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Yuan B, Zhou X, You Z, Xu W, Fan J, Chen S, et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis. 2020;11:76 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...
Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher
  • immunohistochemistry; mouse; 1:800; loading ...; fig s4
Su J, Charalambakis N, Sabbagh U, Somaiya R, Monavarfeshani A, Guido W, et al. Retinal inputs signal astrocytes to recruit interneurons into visual thalamus. Proc Natl Acad Sci U S A. 2020;117:2671-2682 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3k
Sivaraj K, Dharmalingam B, Mohanakrishnan V, Jeong H, Kato K, Schröder S, et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 3d
Qiao H, Tan X, Lv D, Xing R, Shu F, Zhong C, et al. Phosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis. J Cancer. 2020;11:1027-1037 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5c
Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, et al. Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice. Nat Commun. 2020;11:220 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3e
He Y, Li W, Zheng Z, Zhao L, Li W, Wang Y, et al. Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics. 2020;10:133-150 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6b
Xing T, Benderman L, Sabu S, Parker J, Yang J, Lu Q, et al. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Cell Mol Gastroenterol Hepatol. 2020;9:641-659 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s1c
  • western blot; mouse; 1:1000; loading ...; fig s3c
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7e
Zeng S, Bai J, Jiang H, Zhu J, Fu C, He M, et al. Treatment With Liraglutide Exerts Neuroprotection After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway. Front Cell Neurosci. 2019;13:585 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 7c
  • western blot; rat; loading ...; fig 4c
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H. Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. Aging (Albany NY). 2019;11:12532-12545 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Zuo Z, Ji M, Zhao K, Su Z, Li P, Hou D, et al. CD47 Deficiency Attenuates Isoproterenol-Induced Cardiac Remodeling in Mice. Oxid Med Cell Longev. 2019;2019:7121763 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s2a
Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, et al. The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration. Acta Neuropathol Commun. 2019;7:199 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:2000; loading ...; fig 6f
  • immunohistochemistry - frozen section; mouse; 1:2000; loading ...; fig 3g
Bendriem R, Singh S, Aleem A, Antonetti D, Ross M. Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 8a
Power M, Rogerson L, Schubert T, Berens P, Euler T, Paquet Durand F. Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration. J Comp Neurol. 2019;: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s3b
Momcilovic M, Jones A, Bailey S, Waldmann C, Li R, Lee J, et al. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019;575:380-384 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3p
Lummis N, Sánchez Pavón P, Kennedy G, Frantz A, Kihara Y, Blaho V, et al. LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction. Sci Adv. 2019;5:eaax2011 pubmed publisher
  • western blot; mouse; loading ...; fig 2i
Oka S, Chin A, Park J, Ikeda S, Mizushima W, Ralda G, et al. Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart. Cardiovasc Res. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 8c
Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Tang C, Han H, Liu Z, Liu Y, Yin L, Cai J, et al. Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury. Cell Death Dis. 2019;10:677 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s2k
Cheng C, Biton M, Haber A, Gunduz N, Eng G, Gaynor L, et al. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019;178:1115-1131.e15 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Cammalleri M, Dal Monte M, Locri F, Pecci V, De Rosa M, Pavone V, et al. The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model. J Cell Mol Med. 2019;23:5176-5192 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s3i
Diéguez Hurtado R, Kato K, Giaimo B, Nieminen Kelhä M, Arf H, Ferrante F, et al. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019;10:2817 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2d
  • western blot; mouse; 1:1000; loading ...; fig 6f
Jung S, Choe S, Woo H, Jeong H, An H, Moon H, et al. Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Autophagy. 2019;:1-19 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5e
Ommer A, Figlia G, Pereira J, Datwyler A, Gerber J, Degeer J, et al. Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system. J Cell Biol. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 2c
Hou N, He X, Yang Y, Fu J, Zhang W, Guo Z, et al. TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway. Biomed Res Int. 2019;2019:6712536 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Hegde G, de la Cruz C, Giltnane J, Crocker L, Venkatanarayan A, Schaefer G, et al. NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma. elife. 2019;8: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1g
Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3
Frischknecht L, Britschgi C, Galliker P, Christinat Y, Vichalkovski A, Gstaiger M, et al. BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly. Sci Rep. 2019;9:7779 pubmed publisher
  • western blot; rat; fig 3c
  • western blot; human; loading ...; fig 3c
Liu X, Zhao P, Wang X, Wang L, Zhu Y, Song Y, et al. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. J Exp Clin Cancer Res. 2019;38:184 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3a
Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, et al. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells. Cell. 2019;177:1172-1186.e14 pubmed publisher
  • immunohistochemistry; mouse; 0.05 ug/ml; loading ...; fig 1a, s1i
  • western blot; mouse; loading ...; fig s2d
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • western blot; human; loading ...; fig e8d
Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
  • immunocytochemistry; human; fig 1c
  • western blot; human; fig 4a
Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig s1a
Li W, Feng G, Gauthier J, Lokshina I, Higashikubo R, Evans S, et al. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation. J Clin Invest. 2019;129:2293-2304 pubmed publisher
  • western blot; human; loading ...; fig 4c
Yan M, Wang J, Ren Y, Li L, He W, Zhang Y, et al. Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization. Cell Death Dis. 2019;10:204 pubmed publisher
  • western blot; mouse; loading ...; fig 4d
Lin K, Qiang W, Zhu M, Ding Y, Shi Q, Chen X, et al. Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b. Cell Rep. 2019;26:2434-2450.e6 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3h
Bae D, Moore K, Mella J, Hayashi S, Hollien J. Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress. J Cell Biol. 2019;218:1118-1127 pubmed publisher
  • western blot; human; loading ...; fig 8f
Yambire K, Fernández Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, et al. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 4c
Dufour F, Silina L, Neyret Kahn H, Moreno Vega A, Krucker C, Karboul N, et al. TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer. Br J Cancer. 2019;120:555-564 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s3b
Zhang Q, Ji S, Busayavalasa K, Yu C. SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019;5:eaau9780 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5d
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3g
Gronke K, Hernandez P, Zimmermann J, Klose C, Kofoed Branzk M, Guendel F, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019;566:249-253 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1k
Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 3e
  • western blot; mouse; 1:1000; loading ...
Gerber D, Ghidinelli M, Tinelli E, Somandin C, Gerber J, Pereira J, et al. Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig s7c
May J, Kouri F, Hurley L, Liu J, Tommasini Ghelfi S, Ji Y, et al. IDH3α regulates one-carbon metabolism in glioblastoma. Sci Adv. 2019;5:eaat0456 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6i
Liu S, Hausmann S, CARLSON S, Fuentes M, Francis J, Pillai R, et al. METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Cell. 2019;176:491-504.e21 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s7c
Moon S, Huang C, Houlihan S, Regunath K, Freed Pastor W, Morris J, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019;176:564-580.e19 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6e
  • western blot; mouse; loading ...; fig 5f
Pan W, Moroishi T, Koo J, Guan K. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019;38:2595-2610 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6b
Liang C, Ma Y, Yong L, Yang C, Wang P, Liu X, et al. Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. Cancer Sci. 2019;110:166-179 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 6c
  • western blot; human; loading ...; fig 3a, 3b
Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, et al. Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. Mol Neurobiol. 2019;56:3368-3379 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s9c
Ruscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig s3a
Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, et al. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018;9:4394 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2d
Walia M, Taylor S, Ho P, Martin T, Walkley C. Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53. Cell Death Dis. 2018;9:844 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3a
Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, et al. Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma. mSphere. 2018;3: pubmed publisher
  • western blot; human; loading ...; fig s5f
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 1g
Taparra K, Wang H, Malek R, Lafargue A, Barbhuiya M, Wang X, et al. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest. 2018;128:4924-4937 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s3
Robbins J, Perfect L, Ribe E, Maresca M, Dangla Valls A, Foster E, et al. Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons. Front Neurosci. 2018;12:504 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Homma T, Kurahashi T, Lee J, Nabeshima A, Yamada S, Fujii J. Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure. Oxid Med Cell Longev. 2018;2018:2812904 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s3d
Yasuda Yamahara M, Rogg M, Yamahara K, Maier J, Huber T, Schell C. AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes. PLoS ONE. 2018;13:e0200487 pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Lin X, Cui M, Xu D, Hong D, Xia Y, Xu C, et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 2018;9:768 pubmed publisher
  • western blot; human; loading ...; fig 4e
Wang H, Bu L, Wang C, Zhang Y, Zhou H, Zhang X, et al. The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70. Cell Death Dis. 2018;9:734 pubmed publisher
  • western blot; human; loading ...; fig 8b
Wang W, Xia Z, Farre J, Subramani S. TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Autophagy. 2018;14:1574-1585 pubmed publisher
  • western blot; human; loading ...; fig 3b
Yang M, Li C, Zhu S, Cao L, Kroemer G, Zeh H, et al. TFAM is a novel mediator of immunogenic cancer cell death. Oncoimmunology. 2018;7:e1431086 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3d
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  • western blot; mouse; loading ...; fig 2h
Bellelli R, Borel V, Logan C, Svendsen J, Cox D, Nye E, et al. Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018;70:707-721.e7 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1c
Peltzer N, Darding M, Montinaro A, Dráber P, Draberova H, Kupka S, et al. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018;557:112-117 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Zhang X, Zhuang R, Wu H, Chen J, Wang F, Li G, et al. A novel role of endocan in alleviating LPS-induced acute lung injury. Life Sci. 2018;202:89-97 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4g
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
  • western blot; human; fig 2e
Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 7d
Janes M, Zhang J, Li L, Hansen R, Peters U, Guo X, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018;172:578-589.e17 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6e
Gong L, Pan X, Lim C, de Polo A, Little J, Yuan Z. A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene. 2018;37:2150-2164 pubmed publisher
  • western blot; human; 1:1000; fig 4f
Wang Y, Yin B, Li D, Wang G, Han X, Sun X. GSDME mediates caspase-3-dependent pyroptosis in gastric cancer. Biochem Biophys Res Commun. 2018;495:1418-1425 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4c
Janečková E, Bíliková P, Matalova E. Osteogenic Potential of Caspases Related to Endochondral Ossification. J Histochem Cytochem. 2017;:22155417739283 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5i
Tseng K, Danilova T, Domanskyi A, Saarma M, Lindahl M, Airavaara M. MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex. Eneuro. 2017;4: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4f
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig 4a
Peuhu E, Salomaa S, De Franceschi N, Potter C, Sundberg J, Pouwels J. Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice. PLoS ONE. 2017;12:e0186628 pubmed publisher
  • western blot; human; loading ...; fig 5b
Padilla J, Carpenter A, Das N, Kandikattu H, López Ongil S, Martinez Lemus L, et al. TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol. 2018;314:H52-H64 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig s4a
Paikari A, D Belair C, Saw D, Blelloch R. The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017;144:3731-3743 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1h
Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1g
  • western blot; human; loading ...; fig s9b
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 3g
Turrell F, Kerr E, Gao M, Thorpe H, Doherty G, Cridge J, et al. Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity. Genes Dev. 2017;31:1339-1353 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 13b
Smith R, Huang Y, Tian T, Vojtasova D, Mesalles Naranjo O, Pollard S, et al. The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk. J Neurosci. 2017;37:7975-7993 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 9e
  • western blot; human; loading ...; fig 9a
Wang W, Xia Z, Farré J, Subramani S. TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import. J Cell Biol. 2017;216:2843-2858 pubmed publisher
  • western blot; rat; loading ...; fig 6p
Shi Y, Zhang X, Chen C, Tang M, Wang Z, Liang X, et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways. Brain Behav Immun. 2017;66:244-256 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4a
van Vliet P, Lin L, Boogerd C, Martin J, Andelfinger G, Grossfeld P, et al. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017;429:249-259 pubmed publisher
  • western blot; human; loading ...; fig 2b
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig s2g
Ho L, van Dijk M, Chye S, Messerschmidt D, Chng S, Ong S, et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017;357:707-713 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5b
Wang R, Cao X, Kulej K, Liu W, Ma T, MacDonald M, et al. Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114:E5352-E5361 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig s2g
Lim J, Ibaseta A, Fischer M, Cancilla B, O Young G, Cristea S, et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017;545:360-364 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, et al. Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase. Biochem Pharmacol. 2017;137:29-50 pubmed publisher
  • immunohistochemistry; human; 1:400; fig s1d
Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher
  • immunocytochemistry; mouse; 1:400; fig 3c
Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4
Hou J, Xue J, Lee M, Sung C. Ginsenoside Rd as a potential neuroprotective agent prevents trimethyltin injury. Biomed Rep. 2017;6:435-440 pubmed publisher
  • western blot; human; loading ...; fig 4c
He M, Tan B, Vasan K, Yuan H, Cheng F, Ramos da Silva S, et al. SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells. J Pathol. 2017;242:309-321 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a, 1b, 2h
Ahmed S, Macara I. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nat Commun. 2017;8:14867 pubmed publisher
  • western blot; mouse; 1:500; fig 6a
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; fig 3f
Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher
  • western blot; rat; 1:200; loading ...; fig 2d
Chambers T, Santiesteban L, Gomez D, Chambers J. Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity. Toxicology. 2017;382:24-35 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 7e
Huang H, Liu Y, Wang L, Li W. Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS ONE. 2017;12:e0173716 pubmed publisher
  • western blot; mouse; fig 4b
Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 7a
Strangward P, Haley M, Shaw T, Schwartz J, Greig R, Mironov A, et al. A quantitative brain map of experimental cerebral malaria pathology. PLoS Pathog. 2017;13:e1006267 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher
  • western blot; human; loading ...; fig 1f
Li K, Mo C, Gong D, Chen Y, Huang Z, Li Y, et al. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer Lett. 2017;400:194-202 pubmed publisher
  • western blot; human; loading ...; fig 1f
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4d
Cen M, Hu P, Cai Z, Fang T, Zhang J, Lu M. TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway. Int J Mol Med. 2017;39:569-578 pubmed publisher
  • immunohistochemistry - paraffin section; African green monkey; 1:800; loading ...; fig st5
  • immunohistochemistry - paraffin section; rat; 1:800; loading ...; fig st5
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig st5
  • immunohistochemistry - paraffin section; mouse; 1:800; loading ...; fig st5
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 8d
Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed publisher
  • western blot; mouse; loading ...; fig 12A
Shen C, Zhou J, Wang X, Yu X, Liang C, Liu B, et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway. EBioMedicine. 2017;16:238-250 pubmed publisher
  • western blot; human; fig 4c
Mori J, Tanikawa C, Ohnishi N, Funauchi Y, Toyoshima O, Ueda K, et al. EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Neoplasia. 2017;19:185-195 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4a
Vendetti F, Leibowitz B, Barnes J, Schamus S, Kiesel B, Abberbock S, et al. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep. 2017;7:41892 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s4
Bruce F, Brown S, Smith J, Fuerst P, Erskine L. DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A. 2017;114:1702-1707 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4e
Weeden C, Chen Y, Ma S, Hu Y, Ramm G, Sutherland K, et al. Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway. PLoS Biol. 2017;15:e2000731 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Cai L, Wang H, Yang Q. CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma. Oncol Lett. 2017;13:51-56 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 2c
  • western blot; human; 1:1000; loading ...; fig 6b
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, et al. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PLoS ONE. 2017;12:e0170391 pubmed publisher
  • western blot; human; loading ...; fig 2d
Cao H, Yu S, Chen D, Jing C, Wang Z, Ma R, et al. Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio. 2017;7:35-43 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8a
Aksoy P, Meneses P. The Role of DCT in HPV16 Infection of HaCaTs. PLoS ONE. 2017;12:e0170158 pubmed publisher
  • flow cytometry; human; fig s1
Sizdahkhani S, Feldman M, Piazza M, Ksendzovsky A, Edwards N, Ray Chaudhury A, et al. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Sci Rep. 2017;7:40822 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6e
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  • western blot; rat; fig 6a
Ceulemans L, Verbeke L, Decuypere J, Farre R, De Hertogh G, Lenaerts K, et al. Farnesoid X Receptor Activation Attenuates Intestinal Ischemia Reperfusion Injury in Rats. PLoS ONE. 2017;12:e0169331 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3d
Liu X, Shao Z, Jiang W, Lee B, Zha S. PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nat Commun. 2017;8:13816 pubmed publisher
  • immunohistochemistry - frozen section; rat
Dergilev K, Makarevich P, Tsokolaeva Z, Boldyreva M, Beloglazova I, Zubkova E, et al. Comparison of cardiac stem cell sheets detached by Versene solution and from thermoresponsive dishes reveals similar properties of constructs. Tissue Cell. 2017;49:64-71 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...
Erekat N. Cerebellar Purkinje cells die by apoptosis in the shaker mutant rat. Brain Res. 2017;1657:323-332 pubmed publisher
  • western blot; mouse; 1:500; loading ...
Song L, Yu A, Murray K, Cortopassi G. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017;1657:232-244 pubmed publisher
  • western blot; human; loading ...; fig 7c
Sun J, Liu X, Gao H, Zhang L, Ji Q, Wang Z, et al. Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis. Oncotarget. 2017;8:11489-11506 pubmed publisher
  • flow cytometry; human; loading ...; fig s7e
Damas N, Marcatti M, Come C, Christensen L, Nielsen M, Baumgartner R, et al. SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nat Commun. 2016;7:13875 pubmed publisher
  • western blot; rat; loading ...; fig 5a
Leow S, Chua S, Venkatachalam G, Shen L, Luo L, Clement M. Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway. Oncotarget. 2017;8:16170-16189 pubmed publisher
  • western blot; rat; loading ...; fig 7b
Wang F, Jia J, Lal N, Zhang D, Chiu A, Wan A, et al. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 2016;112:656-668 pubmed
  • western blot; human; loading ...; fig 2a
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Morishita M, Kawamoto T, Hara H, Onishi Y, Ueha T, Minoda M, et al. AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway. Int J Oncol. 2017;50:23-30 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig 6a
Paris N, Soroka A, Klose A, Liu W, Chakkalakal J. Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration. elife. 2016;5: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2i
Roversi F, Pericole F, Machado Neto J, da Silva Santos Duarte A, Longhini A, Corrocher F, et al. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway. Biochim Biophys Acta Mol Basis Dis. 2017;1863:450-461 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...
Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello Grand M, et al. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. J Clin Invest. 2016;126:4585-4602 pubmed publisher
  • western blot; human; loading ...; fig 4a
Kitsati N, Mantzaris M, Galaris D. Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation. Redox Biol. 2016;10:233-242 pubmed publisher
  • flow cytometry; human; 1:800; loading ...; fig 3b
  • immunocytochemistry; human; 1:800; loading ...; fig 4d
  • western blot; human; 1:500
Kunzler A, Zeidán Chuliá F, Gasparotto J, Girardi C, Klafke K, Petiz L, et al. Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress. Mol Neurobiol. 2017;54:6903-6916 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 5f
Fielitz K, Althoff K, De Preter K, Nonnekens J, Ohli J, Elges S, et al. Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells. Oncotarget. 2016;7:74415-74426 pubmed publisher
  • western blot; rat; loading ...; fig 5b
Ulbrich F, Kaufmann K, Meske A, Lagrèze W, Augustynik M, Buerkle H, et al. The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells. PLoS ONE. 2016;11:e0165182 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Southard S, Kim J, Low S, Tsika R, Lepper C. Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency. elife. 2016;5: pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 3h
Pang Y, Dai X, Roller A, Carter K, Paul I, Bhatt A, et al. Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats. PLoS ONE. 2016;11:e0164403 pubmed publisher
  • western blot; human; loading ...; fig 1c
Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3C
  • western blot; human; loading ...; fig 3F
Yoffe Y, David M, Kalaora R, Povodovski L, Friedlander G, Feldmesser E, et al. Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells. Genes Dev. 2016;30:1991-2004 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6c
Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Krepler C, Xiao M, Samanta M, Vultur A, Chen H, Brafford P, et al. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016;7:71211-71222 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 9d
Hayes H, Zhang L, Becker T, Haldeman J, Stephens S, Arlotto M, et al. A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. Mol Cell Biol. 2016;36:2918-2930 pubmed publisher
  • immunocytochemistry; rat; 1:200; loading ...; fig 9a, 9b
Olianas M, Dedoni S, Onali P. LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells. J Pharmacol Exp Ther. 2016;359:340-353 pubmed
  • western blot; human; fig 2
  • western blot; rat; fig 6
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7d
Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig s3b
Muzumdar M, Dorans K, Chung K, Robbins R, Tammela T, Gocheva V, et al. Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. Nat Commun. 2016;7:12685 pubmed publisher
  • immunocytochemistry; human; fig 7e
Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, et al. ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy. 2016;12:2167-2182 pubmed
  • western blot; human; 1:1000; loading ...; fig 4b
Yuan S, Pardue S, Shen X, Alexander J, Orr A, Kevil C. Hydrogen sulfide metabolism regulates endothelial solute barrier function. Redox Biol. 2016;9:157-166 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 7b
Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed publisher
  • western blot; human; loading ...; fig 2a
Li H, Yang X, Wang G, Li X, Tao D, Hu J, et al. KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer. Oncotarget. 2016;7:57866-57877 pubmed publisher
  • western blot; rat; fig 2a
Bartlett J, Trivedi P, Yeung P, Kienesberger P, Pulinilkunnil T. Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016;473:3769-3789 pubmed
  • western blot; mouse; 1:500; loading ...; fig 2d
Zhang L, Ren F, Zhang X, Wang X, Shi H, Zhou L, et al. Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Dis Model Mech. 2016;9:799-809 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig s1
Freddo A, Shoffner S, Shao Y, Taniguchi K, Grosse A, Guysinger M, et al. Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding. Integr Biol (Camb). 2016;8:918-28 pubmed publisher
  • immunohistochemistry; purple urchin; 1:250; fig 4
Krupke O, Zysk I, Mellott D, Burke R. Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos. elife. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 3f, 6a
Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 2
Alves S, Marais T, Biferi M, Furling D, Marinello M, El Hachimi K, et al. Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. Mol Neurodegener. 2016;11:58 pubmed publisher
  • western blot; mouse; fig 7
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, et al. Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. Oncotarget. 2016;7:56030-56044 pubmed publisher
  • western blot; human; loading ...; fig s1c
Ho J, Hsu R, Wu C, Liao G, Gao H, Wang T, et al. Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2. Oncotarget. 2016;7:53853-53868 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
  • immunohistochemistry; rhesus macaque; loading ...; fig 6e
DeGottardi M, Okoye A, Vaidya M, Talla A, Konfe A, Reyes M, et al. Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol. 2016;197:1183-98 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Gygli P, Chang J, Gokozan H, Catacutan F, Schmidt T, Kaya B, et al. Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY). 2016;8:1540-70 pubmed publisher
  • western blot; human; 1:1000; fig 4
Belvedere R, Bizzarro V, Forte G, Dal Piaz F, Parente L, Petrella A. Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway. Sci Rep. 2016;6:29660 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, et al. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016;6:29588 pubmed publisher
  • immunocytochemistry; mouse; 1:400; fig s1f
Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s2b
Boogerd C, Aneas I, Sakabe N, Dirschinger R, Cheng Q, Zhou B, et al. Probing chromatin landscape reveals roles of endocardial TBX20 in septation. J Clin Invest. 2016;126:3023-35 pubmed publisher
  • western blot; human; fig 4e
Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, et al. SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Cancer Sci. 2016;107:1270-80 pubmed publisher
  • western blot; human; 1:500; loading ...; fig s6a
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed publisher
  • western blot; human; 1:1000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 6d
Hall Z, Ament Z, Wilson C, Burkhart D, Ashmore T, Koulman A, et al. Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer. Cancer Res. 2016;76:4608-18 pubmed publisher
  • western blot; human; 1:1000; fig s5
Hong A, Tseng Y, Cowley G, Jonas O, Cheah J, Kynnap B, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016;7:11987 pubmed publisher
  • western blot; human; loading ...; fig 3c
Ono H, Basson M, Ito H. P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer. Oncotarget. 2016;7:51301-51310 pubmed publisher
  • western blot; human; 1:1000; fig 5
Meinhardt G, Saleh L, Otti G, Haider S, Velicky P, Fiala C, et al. Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep. 2016;6:28127 pubmed publisher
  • western blot; human; loading ...; fig 7b
Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
  • western blot; mouse; fig 5
Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
  • western blot; human; fig 3
Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium?sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2b
Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, et al. Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression. Am J Pathol. 2016;186:1874-1889 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 10
  • western blot; human
Xue H, Yuan G, Guo X, Liu Q, Zhang J, Gao X, et al. A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway. Autophagy. 2016;12:1129-52 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3
Silva S, Levy D, Ruiz J, de Melo T, Isaac C, Fidelis M, et al. Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. J Steroid Biochem Mol Biol. 2017;169:164-175 pubmed publisher
  • immunohistochemistry - paraffin section; zebrafish ; 1:250; fig 5
He S, Mansour M, Zimmerman M, Ki D, Layden H, Akahane K, et al. Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. elife. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 2c
Wang W, Zhan M, Li Q, Chen W, Chu H, Huang Q, et al. FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. Oncotarget. 2016;7:34617-29 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s3
Chatterjee I, Baruah J, Lurie E, Wary K. Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res. 2016;111:105-18 pubmed publisher
  • immunohistochemistry - paraffin section; chicken; 1:400; fig s5
McKey J, Martire D, de Santa Barbara P, Faure S. LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors. BMC Biol. 2016;14:34 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Hull T, Boddu R, Guo L, Tisher C, Traylor A, Patel B, et al. Heme oxygenase-1 regulates mitochondrial quality control in the heart. JCI Insight. 2016;1:e85817 pubmed
  • immunohistochemistry - frozen section; rat; 1:100; fig 3
  • western blot; rat; 1:1000; fig 3
Delbary Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, et al. A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. Brain. 2016;139:1762-82 pubmed publisher
  • western blot; human; fig 4
Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed publisher
  • western blot; human; loading ...; fig 5e
Slørdahl T, Abdollahi P, Vandsemb E, Rampa C, Misund K, Baranowska K, et al. The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7:27295-306 pubmed publisher
  • western blot; human; 1:1000; fig 4
Cheng C, Jiao J, Qian Y, Guo X, Huang J, Dai M, et al. Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells. Mol Med Rep. 2016;13:3763-70 pubmed publisher
  • western blot; human; loading ...; fig 7a
Sumiyoshi H, Matsushita A, Nakamura Y, Matsuda Y, Ishiwata T, Naito Z, et al. Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion. Oncol Rep. 2016;35:3216-26 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 5
Lian Y, Yuan J, Cui Q, Feng Q, Xu M, Bei J, et al. Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma. PLoS ONE. 2016;11:e0152820 pubmed publisher
  • western blot; human; fig 4
Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 4
Jun S, Jung Y, Suh H, Wang W, Kim M, Oh Y, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016;7:10994 pubmed publisher
  • western blot; human; 1:500; fig 3
Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher
  • western blot; African green monkey; fig s4
Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, et al. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016;107:734-45 pubmed publisher
  • western blot; human; loading ...; fig 1a
Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochem Biophys Res Commun. 2016;473:490-6 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c
Wong C, Poulin K, Tong G, Christou C, Kennedy M, Falls T, et al. Adenovirus-Mediated Expression of the p14 Fusion-Associated Small Transmembrane Protein Promotes Cancer Cell Fusion and Apoptosis In Vitro but Does Not Provide Therapeutic Efficacy in a Xenograft Mouse Model of Cancer. PLoS ONE. 2016;11:e0151516 pubmed publisher
  • western blot; human; 1:1000; fig 4f
Ranjan K, Pathak C. FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016;6:22787 pubmed publisher
  • western blot; human; fig 2
Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5g
  • western blot; mouse; 1:1000; loading ...; fig 5d
Zhao H, Wang H, Bauzon F, Lu Z, Fu H, Cui J, et al. Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis. J Biol Chem. 2016;291:10201-9 pubmed publisher
  • western blot; mouse; loading ...; fig 3c-d
Wang G, Liu X, Gaertig M, Li S, Li X. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016;113:3359-64 pubmed publisher
  • western blot; mouse; fig 1
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 7
  • western blot; mouse; 1:1000; fig 7
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 3b
Yang S, Meng J, Yang Y, Liu H, Liu J, Zhang Y, et al. A HSP60-targeting peptide for cell apoptosis imaging. Oncogenesis. 2016;5:e201 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig s8
Eriksson J, Le Joncour V, Nummela P, Jahkola T, Virolainen S, Laakkonen P, et al. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget. 2016;7:15065-92 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig s1a-c
Waldeck K, Cullinane C, Ardley K, Shortt J, Martin B, Tothill R, et al. Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model. Int J Cancer. 2016;139:194-204 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 2
Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, et al. Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. J Pathol. 2016;239:97-108 pubmed publisher
  • western blot; human; loading ...; fig 3a
Liao B, McManus S, Hughes W, Schmitz Peiffer C. Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes. Mol Endocrinol. 2016;30:417-28 pubmed publisher
  • western blot; human; 1:400; fig 4
Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 5
Sun H, Luo L, Lal B, Ma X, Chen L, Hann C, et al. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun. 2016;7:10339 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Esfandiari A, Hawthorne T, Nakjang S, Lunec J. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016;15:379-91 pubmed publisher
  • western blot; human; fig 2
Podmirseg S, Jäkel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed publisher
  • western blot; human; 1:1000; fig 3
Long C, Guo W, Zhou H, Wang J, Wang H, Sun X. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells. Int J Oncol. 2016;48:1519-30 pubmed publisher
  • western blot; human; loading ...; fig 3a
Liu X, Ward K, Xavier C, Jann J, Clark A, Pang I, et al. The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. Redox Biol. 2016;8:98-109 pubmed publisher
  • western blot; human; fig 3, 4
Crowder R, Dicker D, El Deiry W. The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death. J Biol Chem. 2016;291:5960-70 pubmed publisher
  • western blot; human; 1:500; fig 5
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
  • western blot; human; 1:1000; fig s5
  • immunohistochemistry - frozen section; mouse; 1:100; fig 2
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher
  • western blot; mouse; fig 3c
Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, et al. YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Oncogene. 2016;35:4256-68 pubmed publisher
  • western blot; mouse; fig 1
Suga K, Saito A, Akagawa K. Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion. Data Brief. 2015;5:782-8 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • western blot; mouse; fig 5
Kaizuka T, Mizushima N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol Cell Biol. 2016;36:585-95 pubmed publisher
  • western blot; human; fig 6
Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
  • western blot; human; fig 4
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; mouse; fig 1
Ashraf M, Schwelberger H, Brendel K, Feurle J, Andrassy J, Kotsch K, et al. Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation. Am J Transplant. 2016;16:808-20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7A
Wang Z, Liu N, Liu K, Zhou G, Gan J, Wang Z, et al. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy. 2015;11:2358-69 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 4c
Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Shankaraiah R, Seano G, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. J Natl Cancer Inst. 2016;108: pubmed publisher
  • western blot; mouse; 1:1000; fig s2
  • western blot; human; 1:1000; fig 1
Kyathanahalli C, Organ K, Moreci R, Anamthathmakula P, Hassan S, Caritis S, et al. Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci U S A. 2015;112:14090-5 pubmed publisher
  • western blot; human; loading ...; fig 2e
Li K, Gao B, Li J, Chen H, Li Y, Wei Y, et al. ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 2015;6:38107-26 pubmed publisher
  • western blot; human; fig 6
Spiesberger K, Paulfranz F, Egger A, Reiser J, Vogl C, Rudolf Scholik J, et al. Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle. PLoS ONE. 2015;10:e0140471 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig s2
Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, et al. ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016;19:53-65 pubmed publisher
  • western blot; rat; 1:1000; fig 7
Liu L, Li C, Lu Y, Zong X, Luo C, Sun J, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015;5:14474 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; 1:100
Werner A, Iwasaki S, McGourty C, Medina Ruiz S, Teerikorpi N, Fedrigo I, et al. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015;525:523-7 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4
Pearson H, McGlinn E, Phesse T, Schlüter H, Srikumar A, Gödde N, et al. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Mol Cancer. 2015;14:169 pubmed publisher
  • western blot; human
Sirohi K, Kumari A, Radha V, Swarup G. A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS ONE. 2015;10:e0138289 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400; fig 6
Hasan S, Sultana S. Geraniol attenuates 2-acetylaminofluorene induced oxidative stress, inflammation and apoptosis in the liver of wistar rats. Toxicol Mech Methods. 2015;25:559-73 pubmed publisher
  • western blot; rat; fig 3c
Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, et al. Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis. Sci Rep. 2015;5:13737 pubmed publisher
  • western blot; human; fig 4
Bida O, Gidoni M, Ideses D, Efroni S, Ginsberg D. A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel. Oncotarget. 2015;6:27880-90 pubmed publisher
  • western blot; human; fig 6
Heishima K, Mori T, Sakai H, Sugito N, Murakami M, Yamada N, et al. MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis. PLoS ONE. 2015;10:e0137361 pubmed publisher
  • immunocytochemistry; human; fig 7a
Salva K, Wood G. Epigenetically Enhanced Photodynamic Therapy (ePDT) is Superior to Conventional Photodynamic Therapy for Inducing Apoptosis in Cutaneous T-Cell Lymphoma. Photochem Photobiol. 2015;91:1444-51 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s7a
Manieri N, Mack M, Himmelrich M, Worthley D, Hanson E, Eckmann L, et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. J Clin Invest. 2015;125:3606-18 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Veselá B, Svandová E, Vanden Berghe T, Tucker A, Vandenabeele P, Matalova E. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. J Mol Histol. 2015;46:443-55 pubmed publisher
  • flow cytometry; human; 1:250; fig 4
Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek S, et al. α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Stem Cell Reports. 2015;5:195-206 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 5
He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig 2
Nuccitelli R, Berridge J, Mallon Z, Kreis M, Athos B, Nuccitelli P. Nanoelectroablation of Murine Tumors Triggers a CD8-Dependent Inhibition of Secondary Tumor Growth. PLoS ONE. 2015;10:e0134364 pubmed publisher
  • western blot; rat; fig 6
Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch Puy E, Hotter G, et al. Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE. 2015;10:e0134499 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4b
Marzagalli M, Casati L, Moretti R, Montagnani Marelli M, Limonta P. Estrogen Receptor β Agonists Differentially Affect the Growth of Human Melanoma Cell Lines. PLoS ONE. 2015;10:e0134396 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Lim G, Albrecht T, Piske M, Sarai K, Lee J, Ramshaw H, et al. 14-3-3ζ coordinates adipogenesis of visceral fat. Nat Commun. 2015;6:7671 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig s3
Parchem R, Moore N, Fish J, Parchem J, Braga T, Shenoy A, et al. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015;12:760-73 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Jiao L, Inhoffen J, Gan Schreier H, Tuma Kellner S, Stremmel W, Sun Z, et al. Deficiency of Group VIA Phospholipase A2 (iPLA2β) Renders Susceptibility for Chemical-Induced Colitis. Dig Dis Sci. 2015;60:3590-602 pubmed publisher
  • western blot; human; fig 6
Jiang S, Zou Z, Nie P, Wen R, Xiao Y, Tang J. Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells. PLoS ONE. 2015;10:e0132880 pubmed publisher
  • western blot; human; 1:5000
Demel H, Feuerecker B, Piontek G, Seidl C, Blechert B, Pickhard A, et al. Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. Am J Cancer Res. 2015;5:1649-64 pubmed
  • immunocytochemistry; mouse; fig 6d
Quintana P, Soto D, Poirot O, Zonouzi M, Kellenberger S, Muller D, et al. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. J Physiol. 2015;593:4373-86 pubmed publisher
  • immunocytochemistry; human; fig 2
Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed
  • western blot; human; fig 2
Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016;35:1541-53 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016;415:306-313 pubmed publisher
  • immunocytochemistry; mouse
Yuri S, Nishikawa M, Yanagawa N, Jo O, Yanagawa N. Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor. PLoS ONE. 2015;10:e0129242 pubmed publisher
  • immunohistochemistry - paraffin section; human
Hirt C, Papadimitropoulos A, Muraro M, Mele V, Panopoulos E, Cremonesi E, et al. Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo". Biomaterials. 2015;62:138-46 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 5c
Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller Holzner E, Watson C, et al. The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland. Cell Death Differ. 2016;23:41-51 pubmed publisher
  • western blot; human; 1:800; fig  4
Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, et al. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015;150:139-49 pubmed publisher
  • western blot; mouse; 1:200; fig 8
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; fig 7
  • western blot; mouse; fig s10
Kang J, Shen W, Zhou C, Xu D, Macdonald R. The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration. Nat Neurosci. 2015;18:988-96 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4e
Hua W, Huang H, Tan L, Wan J, Gui H, Zhao L, et al. CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress. PLoS ONE. 2015;10:e0127507 pubmed publisher
  • western blot; human; 1:1000; fig 5
Han Y, Lee J, Lee S. Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways. Mol Med Rep. 2015;12:3446-3452 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig s8
Klotz L, Norman S, Vieira J, Masters M, Rohling M, Dubé K, et al. Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature. 2015;522:62-7 pubmed
  • immunocytochemistry; human; fig 1
Coudé M, Braun T, Berrou J, Dupont M, Bertrand S, Massé A, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015;6:17698-712 pubmed
  • western blot; rat; fig 8
Matsumoto T, Urushido M, Ide H, Ishihara M, Hamada Ode K, Shimamura Y, et al. Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE. 2015;10:e0126229 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800
Sarr D, Bracken T, Owino S, Cooper C, Smith G, Nagy T, et al. Differential roles of inflammation and apoptosis in initiation of mid-gestational abortion in malaria-infected C57BL/6 and A/J mice. Placenta. 2015;36:738-49 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4a
  • western blot; mouse
Deutsch M, Graffeo C, Rokosh R, Pansari M, Ochi A, Levie E, et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015;6:e1759 pubmed publisher
  • western blot; human; 1:1000; fig 3
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  • western blot; human
Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015;14:1559-69 pubmed publisher
  • western blot; human; loading ...; fig 4e
Baker E, Taylor S, Gupte A, Sharp P, Walia M, Walsh N, et al. BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Sci Rep. 2015;5:10120 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 6
Liu H, Du L, Wang R, Wei C, Liu B, Zhu L, et al. High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy. Oncotarget. 2015;6:11477-91 pubmed
  • immunohistochemistry; mouse; 1:200
Vong K, Leung C, Behringer R, Kwan K. Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25 pubmed publisher
  • western blot; mouse; fig 5
Bettaieb A, Jiang J, Sasaki Y, Chao T, Kiss Z, Chen X, et al. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015;149:468-80.e10 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s1
Wilson C, Jurk D, Fullard N, Banks P, Page A, Luli S, et al. NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; fig 7
Pértega Gomes N, Felisbino S, Massie C, Vizcaíno J, Coelho R, Sandi C, et al. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy. J Pathol. 2015;236:517-30 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4
  • western blot; human; 1:1000; fig 1
Meidhof S, Brabletz S, Lehmann W, Preca B, Mock K, Ruh M, et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med. 2015;7:831-47 pubmed publisher
  • western blot; human; fig 8c
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Szabo N, Da Silva R, Sotocinal S, Zeilhofer H, Mogil J, Kania A. Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015;35:5233-46 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3a
Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s9
Ngo J, Matsuyama M, Kim C, Poventud Fuentes I, Bates A, Siedlak S, et al. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death Dis. 2015;6:e1706 pubmed publisher
  • western blot; human; 1:1000; fig 2b
  • western blot; mouse; 1:1000; fig 2c
Popp M, Maquat L. Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nat Commun. 2015;6:6632 pubmed publisher
  • western blot; human
Shen X, Sun W, Shi Y, Xing Z, Su X. Altered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009. Mediators Inflamm. 2015;2015:976575 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5b
  • western blot; mouse; 1:1000; loading ...; fig 5c
  • western blot; human; 1:1000; loading ...; fig 3c
Ma W, Na M, Tang C, Wang H, Lin Z. Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways. Mol Med Rep. 2015;12:1050-8 pubmed publisher
  • western blot; human
Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3e
Quang C, Leboucher S, Passaro D, Fuhrmann L, Nourieh M, Vincent Salomon A, et al. The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. Cell Death Dis. 2015;6:e1658 pubmed publisher
  • western blot; mouse; 1:1000
ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
  • western blot; human; fig 6
Xiang W, He J, Huang C, Chen L, Tao D, Wu X, et al. miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget. 2015;6:4066-79 pubmed
  • western blot; human; fig 4
Kramer D, Schön M, Bayerlová M, Bleckmann A, Schön M, Zörnig M, et al. A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. Cell Death Dis. 2015;6:e1634 pubmed publisher
  • other; zebrafish ; fig S2
Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed publisher
  • western blot; human; fig 3
Long J, Schoonen P, Graczyk D, O Prey J, Ryan K. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. 2015;34:5152-62 pubmed publisher
  • western blot; mouse; fig 2
Suganya R, Chakraborty A, Miriyala S, Hazra T, Izumi T. Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst). 2015;27:40-8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; fig s9
Eikawa S, Nishida M, Mizukami S, Yamazaki C, Nakayama E, Udono H. Immune-mediated antitumor effect by type 2 diabetes drug, metformin. Proc Natl Acad Sci U S A. 2015;112:1809-14 pubmed publisher
  • western blot; mouse
Kim S, Nam S, Friedman M. The Tomato Glycoalkaloid α-Tomatine Induces Caspase-Independent Cell Death in Mouse Colon Cancer CT-26 Cells and Transplanted Tumors in Mice. J Agric Food Chem. 2015;63:1142-1150 pubmed publisher
  • western blot; human
Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed
  • western blot; mouse
Liu L, Zou P, Zheng L, Linarelli L, Amarell S, Passaro A, et al. Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis. 2015;6:e1586 pubmed publisher
  • immunohistochemistry; mouse; fig 3
Hill R, Kuijper S, Lindsey J, Petrie K, Schwalbe E, Barker K, et al. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015;27:72-84 pubmed publisher
  • western blot; human; fig 2
Hennig D, Müller S, Wichmann C, Drube S, Pietschmann K, Pelzl L, et al. Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells. Br J Cancer. 2015;112:329-37 pubmed publisher
  • western blot; mouse; 1:200; fig s6
Suzuki D, Sahu R, Leu N, Senoo M. The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. 2015;142:282-90 pubmed publisher
  • western blot; human
Girotti M, Lopes F, Preece N, Niculescu Duvaz D, Zambon A, Davies L, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015;27:85-96 pubmed publisher
  • western blot; human; fig 3
Chen Y, Wei M, Wang C, Lee H, Pan S, Gao M, et al. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. Cancer Lett. 2015;357:582-90 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s7b
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Bisson J, Mills B, Paul Helt J, Zwaka T, Cohen E. Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015;398:80-96 pubmed publisher
  • western blot; human; 1:1000
Liu W, Lin Y, Yan X, Ding Y, Wu Y, Chen W, et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 2015;29:1113-23 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Healy M, Chow J, Byrne F, Breen D, Leitinger N, Li C, et al. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. J Hepatol. 2015;62:599-606 pubmed publisher
  • western blot; mouse; 1:1000
Nashine S, Liu Y, Kim B, Clark A, Pang I. Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. Invest Ophthalmol Vis Sci. 2014;56:221-31 pubmed publisher
  • immunohistochemistry - paraffin section; human
Somsouk M, Estes J, Deléage C, Dunham R, Albright R, Inadomi J, et al. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015;29:43-51 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; fig 6
  • western blot; mouse; 1:1000; fig 7
Tao W, Moore R, Smith E, Xu X. Hormonal induction and roles of Disabled-2 in lactation and involution. PLoS ONE. 2014;9:e110737 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s4d
Vanhoutteghem A, Messiaen S, Hervé F, Delhomme B, Moison D, Petit J, et al. The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014;141:4298-310 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s2a, b
Baek J, Schmidt E, Viceconte N, Strandgren C, Pernold K, Richard T, et al. Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior. Hum Mol Genet. 2015;24:1305-21 pubmed publisher
  • western blot; mouse; fig 7
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264-78 pubmed publisher
  • western blot; mouse
Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Lockhart M, Boukens B, Phelps A, Brown C, Toomer K, Burns T, et al. Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014;396:8-18 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 7
Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
  • immunocytochemistry; human; fig 4
Goldshmit Y, Trangle S, Kloog Y, Pinkas Kramarski R. Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma. Oncotarget. 2014;5:8602-13 pubmed
  • immunocytochemistry; human; 1:400; loading ...; fig 4d
Zur Bruegge J, Hanisch C, Einspanier R, Alter T, Gölz G, Sharbati S. Arcobacter butzleri induces a pro-inflammatory response in THP-1 derived macrophages and has limited ability for intracellular survival. Int J Med Microbiol. 2014;304:1209-17 pubmed publisher
  • immunohistochemistry; mouse; fig 3
Herranz D, Ambesi Impiombato A, Palomero T, Schnell S, Belver L, Wendorff A, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130-7 pubmed publisher
  • immunohistochemistry; human; 1:50
Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Lin Y, Pang X, Huang G, Jamison S, Fang J, Harding H, et al. Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice. J Neurosci. 2014;34:12182-91 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Valkenburg K, Yu X, De Marzo A, Spiering T, Matusik R, Williams B. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia. Prostate. 2014;74:1506-20 pubmed publisher
  • western blot; human
Kaistha B, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, et al. Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells. Br J Cancer. 2014;111:1780-7 pubmed publisher
  • immunohistochemistry; human; fig 4
Yi T, Kabha E, Papadopoulos E, Wagner G. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014;5:6028-37 pubmed
  • western blot; human
Kemp M, Gaddameedhi S, Choi J, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014;289:26574-83 pubmed publisher
  • western blot; mouse
Deegan S, Saveljeva S, Gupta S, Macdonald D, Samali A. ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. Biochem Biophys Res Commun. 2014;451:367-73 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Ostapoff K, Cenik B, Wang M, Ye R, Xu X, Nugent D, et al. Neutralizing murine TGF?R2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res. 2014;74:4996-5007 pubmed publisher
  • western blot; mouse
Resch U, Cuapio A, Sturtzel C, Hofer E, de Martin R, Holper Schichl Y. Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem. 2014;289:25088-100 pubmed publisher
  • western blot; African green monkey
Kuma A, Yamada S, Wang K, Kitamura N, Yamaguchi T, Iwai Y, et al. Role of WNT10A-expressing kidney fibroblasts in acute interstitial nephritis. PLoS ONE. 2014;9:e103240 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:200
McGraw H, Culbertson M, Nechiporuk A. Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development. 2014;141:3212-21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Jeon H, Kim S, Jin X, Park J, Kim S, Joshi K, et al. Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression. Cancer Res. 2014;74:4482-92 pubmed publisher
  • western blot; rat; 1:500
Kraemer B, Snow J, Vollbrecht P, Pathak A, Valentine W, Deutch A, et al. A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J Biol Chem. 2014;289:21205-16 pubmed publisher
  • immunocytochemistry; mouse; 1:200
  • western blot; mouse; 1:1000
Kaneko Y, Ota A, Nakashima A, Nagasaki H, Kodani Y, Mori K, et al. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G? phase and protects them from UV light-induced apoptosis. J Neural Transm (Vienna). 2015;122:187-99 pubmed publisher
  • western blot; human; loading ...; fig 2c
Benzina S, Harquail J, Jean S, Beauregard A, Colquhoun C, Carroll M, et al. Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells. Anticancer Agents Med Chem. 2015;15:79-88 pubmed
  • western blot; mouse; 1:1000; fig 7
Kukreja L, Kujoth G, Prolla T, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2014;9:16 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:800
Soares F, Tattoli I, Rahman M, Robertson S, Belcheva A, Liu D, et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem. 2014;289:19317-30 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Kielar M, Tuy F, Bizzotto S, Lebrand C, de Juan Romero C, Poirier K, et al. Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Nat Neurosci. 2014;17:923-33 pubmed publisher
  • western blot; mouse; fig 4
Ying Y, Kim J, Westphal S, Long K, Padanilam B. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol. 2014;25:2707-16 pubmed publisher
  • western blot; human; 1:1000
Velicky P, Haider S, Otti G, Fiala C, Pollheimer J, Knöfler M. Notch-dependent RBPJ? inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts. Mol Hum Reprod. 2014;20:756-66 pubmed publisher
  • western blot; mouse; 1:1000; fig 6c
Li T, Yang D, Li J, Tang Y, Yang J, Le W. Critical role of Tet3 in neural progenitor cell maintenance and terminal differentiation. Mol Neurobiol. 2015;51:142-54 pubmed publisher
  • western blot; human; loading ...; fig 6b
Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking ?-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher
  • immunocytochemistry; human; 1:200
Cai L, Wang D, Fisher A, Wang Z. Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells. Biochem Biophys Res Commun. 2014;447:292-8 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Bailey K, Rahimi Balaei M, Mannan A, Del Bigio M, Marzban H. Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse). PLoS ONE. 2014;9:e94327 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, et al. LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. BMC Biol. 2014;12:25 pubmed publisher
  • western blot; rat
Smith I, Godinez G, Singh B, McCaughey K, Alcantara R, Gururaja T, et al. Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction. FASEB J. 2014;28:2790-803 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  • immunohistochemistry; human; 1:200
Hassan H, Varney M, Jain S, Weisenburger D, Singh R, Dave B. Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma. Leuk Lymphoma. 2014;55:2924-31 pubmed publisher
  • western blot; human
Xia Y, Chang T, Wang Y, Liu Y, Li W, Li M, et al. YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PLoS ONE. 2014;9:e91770 pubmed publisher
  • immunocytochemistry; human; 1:400
Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed publisher
  • western blot; human; fig 1
Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1e
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed publisher
  • western blot; rat; 1:1000
Borkham Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-? signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher
  • western blot; human
Li A, Morton J, Ma Y, Karim S, Zhou Y, Faller W, et al. Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology. 2014;146:1386-96.e1-17 pubmed publisher
  • western blot; rat
  • immunohistochemistry - paraffin section; mouse
Li J, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014;86:86-102 pubmed publisher
  • western blot; human
Wang C, Wang J, Liu Z, Ma X, Wang X, Jin H, et al. Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma. Carcinogenesis. 2014;35:1500-9 pubmed publisher
  • western blot; mouse; 1:200
Nandan M, Ghaleb A, Liu Y, Bialkowska A, McConnell B, Shroyer K, et al. Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon. Dev Biol. 2014;387:191-202 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Byron A, Randles M, Humphries J, Mironov A, Hamidi H, Harris S, et al. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol. 2014;25:953-66 pubmed publisher
  • immunohistochemistry; mouse
Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges Labouesse E, Menko A. ?6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014;289:3842-55 pubmed publisher
  • immunocytochemistry; human; 1:100
Clave S, Joya X, Salat Batlle J, Garcia Algar O, Vall O. Ethanol cytotoxic effect on trophoblast cells. Toxicol Lett. 2014;225:216-21 pubmed publisher
  • western blot; human; fig 5
Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Otero J, Kalaszczynska I, Michowski W, Wong M, Gygli P, Gokozan H, et al. Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014;385:328-39 pubmed publisher
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:1000
Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht E, Aberdeen G, et al. Cross-species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon. Endocrinology. 2013;154:4873-84 pubmed publisher
  • western blot; human; 1:50-500
O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed publisher
  • immunohistochemistry; mouse
Zhou D, Tan R, Lin L, Zhou L, Liu Y. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 2013;84:509-20 pubmed publisher
  • western blot; rat
Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher
  • western blot; mouse; 1:200
Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, et al. RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke. Brain Res. 2013;1517:122-32 pubmed publisher
  • western blot; human; 1:1000; fig 3
Backman L, Danielson P. Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes. J Cell Mol Med. 2013;17:723-33 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:400
Bajic D, Commons K, Soriano S. Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013;31:258-66 pubmed publisher
  • western blot; mouse
Valente A, Yoshida T, Clark R, Delafontaine P, Siebenlist U, Chandrasekar B. Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling. Free Radic Biol Med. 2013;60:125-35 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Kim B, Zaveri H, Shchelochkov O, Yu Z, Hernandez Garcia A, Seymour M, et al. An allelic series of mice reveals a role for RERE in the development of multiple organs affected in chromosome 1p36 deletions. PLoS ONE. 2013;8:e57460 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed publisher
  • western blot; rat
Sirohi K, Chalasani M, Sudhakar C, Kumari A, Radha V, Swarup G. M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013;9:510-27 pubmed publisher
  • western blot; human
Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher
  • immunocytochemistry; human
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400
  • western blot; rat; 1:1000
Cao L, Li L, Lin D, Zuo Z. Isoflurane induces learning impairment that is mediated by interleukin 1? in rodents. PLoS ONE. 2012;7:e51431 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, et al. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet. 2013;45:98-103 pubmed publisher
  • immunocytochemistry; dogs
  • western blot; dogs
Cho K, Park J, Piggott A, Salim A, Gorfe A, Parton R, et al. Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins. J Biol Chem. 2012;287:43573-84 pubmed publisher
  • flow cytometry; mouse
Knox S, Lombaert I, Reed X, Vitale Cross L, Gutkind J, Hoffman M. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science. 2010;329:1645-7 pubmed publisher
  • western blot; human
Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Ueno K, et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer. 2011;128:1793-803 pubmed publisher
  • immunohistochemistry; human
D Alessio S, Ferrari G, Cinnante K, Scheerer W, Galloway A, Roses D, et al. Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism. J Biol Chem. 2008;283:87-99 pubmed
Si F, Hu X, Wang C, Chen B, Wang R, Dong S, et al. Porcine Epidemic Diarrhea Virus (PEDV) ORF3 Enhances Viral Proliferation by Inhibiting Apoptosis of Infected Cells. Viruses. 2020;12: pubmed publisher
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher
Howley B, Link L, Grelet S, El Sabban M, Howe P. A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer. Oncogene. 2018;37:1308-1325 pubmed publisher
Robitaille A, Caron E, Zucchini N, Mukawera E, Adam D, Mariani M, et al. DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection. Sci Rep. 2017;7:17388 pubmed publisher
Zhang Y, Chen C, Jiang Y, Wang S, Wu X, Wang K. PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway. BMC Neurosci. 2017;18:69 pubmed publisher
Duggan M, Stiff A, Bainazar M, Regan K, Olaverria Salavaggione G, Maharry S, et al. Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma. Proc Natl Acad Sci U S A. 2017;114:9629-9634 pubmed publisher
Osako M, Itsumi M, Yamaguchi H, Takeuchi H, Yamaoka S. A20 restores phorbol ester-induced differentiation of THP-1 cells in the absence of nuclear factor-κB activation. J Cell Biochem. 2018;119:1475-1487 pubmed publisher
Gallagher E, Zelenko Z, Neel B, Antoniou I, Rajan L, Kase N, et al. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene. 2017;36:6462-6471 pubmed publisher
Zhang P, Zheng Z, Ling L, Yang X, Zhang N, Wang X, et al. w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway. Autophagy. 2017;13:1093-1112 pubmed publisher
Pappas K, Xu J, Zairis S, Resnick Silverman L, Abate F, Steinbach N, et al. p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Mol Cancer Res. 2017;15:1051-1062 pubmed publisher
Ando K, PARSONS M, Shah R, Charendoff C, Paris S, Liu P, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017;216:1795-1810 pubmed publisher
Li Y, Xiang Y, Zhang S, Wang Y, Yang J, Liu W, et al. Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes. Am J Transl Res. 2017;9:1471-1482 pubmed
Dai K, Huang L, Huang Y, Chen Z, Yang L, Jiang Y. 1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model. Front Immunol. 2017;8:320 pubmed publisher
Laird M, Thomson K, Fenwick M, Mora J, Franks S, Hardy K. Androgen Stimulates Growth of Mouse Preantral Follicles In Vitro: Interaction With Follicle-Stimulating Hormone and With Growth Factors of the TGFβ Superfamily. Endocrinology. 2017;158:920-935 pubmed publisher
Thiebaut C, Chamard Jovenin C, Chesnel A, Morel C, Djermoune E, Boukhobza T, et al. Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression. PLoS ONE. 2017;12:e0173931 pubmed publisher
Tang Z, Cao W, Wang Z, Lu J, Liu B, Chen X, et al. Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells. Redox Biol. 2017;12:367-376 pubmed publisher
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product information
SKU :
9664S
Product-Name :
Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (Dg)
Applications :
Flow cytometry
Product-Category :
Apoptosis
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17, 19
Host :
Rabbit
Target :
Casp3 (Asp175) cleaved
Primary-Protein :
Casp3
Alt-Names :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.