This is a Validated Antibody Database (VAD) review about human TCF7L2, based on 34 published articles (read how Labome selects the articles), using TCF7L2 antibody in all methods. It is aimed to help Labome visitors find the most suited TCF7L2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TCF7L2 synonym: TCF-4; TCF4

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (C9B9)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, 2565) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4b). elife (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-4)
  • western blot; human; loading ...; fig 10c
Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, sc-166699) was used in western blot on human samples (fig 10c). Theranostics (2021) ncbi
mouse monoclonal (D-4)
  • western blot; human; loading ...; fig 6a
Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, sc-166699) was used in western blot on human samples (fig 6a). Sci Rep (2020) ncbi
mouse monoclonal (D-4)
  • western blot; human; 1:1000; loading ...; fig 3a
Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, sc-166699) was used in western blot on human samples at 1:1000 (fig 3a). Onco Targets Ther (2020) ncbi
mouse monoclonal (H-7)
  • western blot; mouse; loading ...; fig 4e
Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, sc-271287) was used in western blot on mouse samples (fig 4e). Aging (Albany NY) (2020) ncbi
mouse monoclonal (D-4)
  • western blot; mouse; 1:1000; loading ...; fig 9b
Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, 166699) was used in western blot on mouse samples at 1:1000 (fig 9b). Cell Mol Gastroenterol Hepatol (2020) ncbi
mouse monoclonal (D-4)
  • immunocytochemistry; human; 1:400; loading ...; fig 3d
In order to optimize conditions to generate human pluripotent stem cell-derived limbal epithelial stem cells, Santa Cruz Biotechnology TCF7L2 antibody (Santa Cruz, sc-166699) was used in immunocytochemistry on human samples at 1:400 (fig 3d). Exp Eye Res (2016) ncbi
mouse monoclonal (D-4)
  • immunocytochemistry; human; 1:400; fig 6
Santa Cruz Biotechnology TCF7L2 antibody (santa Cruz, sc-166699) was used in immunocytochemistry on human samples at 1:400 (fig 6). Sci Rep (2015) ncbi
mouse monoclonal (D-4)
  • western blot; human; loading ...; fig 1d
Santa Cruz Biotechnology TCF7L2 antibody (SantaCruz, D-4) was used in western blot on human samples (fig 1d). J Cell Sci (2015) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 1d
Santa Cruz Biotechnology TCF7L2 antibody (SantaCruz, D-4) was used in western blot on human samples (fig 1d). J Cell Sci (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C48H11)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3e
Cell Signaling Technology TCF7L2 antibody (CST, 2569) was used in immunohistochemistry on mouse samples at 1:500 (fig 3e). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; loading ...; fig 2e
Cell Signaling Technology TCF7L2 antibody (CST, 2569) was used in western blot on human samples (fig 2e). iScience (2021) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; mouse; 1:1000; loading ...; fig s7-1e
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, 2569) was used in western blot on mouse samples at 1:1000 (fig s7-1e). elife (2021) ncbi
domestic rabbit monoclonal (C48H11)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, C48H11) was used in immunohistochemistry on mouse samples at 1:100 (fig 5). Dis Model Mech (2021) ncbi
domestic rabbit monoclonal (C9B9)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, 2565) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4b). elife (2020) ncbi
domestic rabbit monoclonal (C48H11)
  • chromatin immunoprecipitation; mouse; 1:400; loading ...; fig 6g
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in chromatin immunoprecipitation on mouse samples at 1:400 (fig 6g). Sci Adv (2020) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; mouse; 1:1000; loading ...; fig 2i
Cell Signaling Technology TCF7L2 antibody (CST, 2569) was used in western blot on mouse samples at 1:1000 (fig 2i). Sci Adv (2019) ncbi
domestic rabbit monoclonal (C48H11)
  • immunoprecipitation; human; 1:100; loading ...; fig 1k
  • western blot; human; 1:1000; loading ...; fig 1k
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569S) was used in immunoprecipitation on human samples at 1:100 (fig 1k) and in western blot on human samples at 1:1000 (fig 1k). Mol Cell (2018) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; 1:1000; loading ...; fig 5b
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in western blot on human samples at 1:1000 (fig 5b). Stem Cells (2017) ncbi
domestic rabbit monoclonal (C48H11)
  • immunohistochemistry - paraffin section; human; 1:100; fig 3e
  • immunohistochemistry; human; 1:100; fig 3e
  • western blot; human; 1:1000; fig 3c
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569S) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 3e), in immunohistochemistry on human samples at 1:100 (fig 3e) and in western blot on human samples at 1:1000 (fig 3c). elife (2017) ncbi
domestic rabbit monoclonal (C48H11)
  • immunohistochemistry - frozen section; human; loading ...; fig 1
In order to suggest that fibroblasts exert a strong positive regulatory influence on myogenic precursor cell activity, Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in immunohistochemistry - frozen section on human samples (fig 1). J Physiol (2017) ncbi
domestic rabbit monoclonal (C48H11)
  • immunohistochemistry - frozen section; human; loading ...; fig 1a
In order to describe the perturbations in skeletal muscle morphology and progenitor cell activity following an anterior cruciate ligament injury, Cell Signaling Technology TCF7L2 antibody (Cell signaling, 2569) was used in immunohistochemistry - frozen section on human samples (fig 1a). J Orthop Res (2017) ncbi
domestic rabbit monoclonal (C9B9)
  • western blot; human; fig s5
In order to analyze the rescue of intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation due to ERK5 signaling, Cell Signaling Technology TCF7L2 antibody (Cell signaling, C9B9) was used in western blot on human samples (fig s5). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; 1:1000; fig 2
  • chromatin immunoprecipitation; mouse; fig 5
  • western blot; mouse; 1:1000; fig 2
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Tech, 2569) was used in western blot on human samples at 1:1000 (fig 2), in chromatin immunoprecipitation on mouse samples (fig 5) and in western blot on mouse samples at 1:1000 (fig 2). Sci Rep (2016) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; fig 4
In order to determine the inhibition of beta-catenin activity in the synovial joint development and osteoarthritis by hedgehog, Cell Signaling Technology TCF7L2 antibody (Cell signaling, 2569) was used in western blot on human samples (fig 4). J Clin Invest (2016) ncbi
domestic rabbit monoclonal (C9B9)
  • immunocytochemistry; rat; loading ...; fig 4d
  • western blot; rat; fig 4i
  • immunoprecipitation; human; loading ...; fig 4i
  • western blot; human; loading ...; fig 4j
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4d
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2565) was used in immunocytochemistry on rat samples (fig 4d), in western blot on rat samples (fig 4i), in immunoprecipitation on human samples (fig 4i), in western blot on human samples (fig 4j) and in immunohistochemistry on mouse samples at 1:500 (fig 4d). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; mouse; loading ...; fig 4c
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, C48H11) was used in western blot on mouse samples (fig 4c). Sci Rep (2016) ncbi
domestic rabbit monoclonal (C48H11)
  • immunoprecipitation; mouse; fig 7
  • western blot; mouse; 1:500; fig 7
In order to report that valproic acid shifts the balance toward pancreatic injury and pancreatitis through histone deacetylase inhibition, Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in immunoprecipitation on mouse samples (fig 7) and in western blot on mouse samples at 1:500 (fig 7). Am J Pathol (2015) ncbi
domestic rabbit monoclonal (C9B9)
  • western blot; human; 1:1000; fig 2
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, C9B9) was used in western blot on human samples at 1:1000 (fig 2). Placenta (2015) ncbi
domestic rabbit monoclonal (C48H11)
  • chromatin immunoprecipitation; human
  • western blot; human; fig 4
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in chromatin immunoprecipitation on human samples and in western blot on human samples (fig 4). Sci Signal (2015) ncbi
mouse monoclonal (L40C3)
  • western blot; human; fig 3
Cell Signaling Technology TCF7L2 antibody (Cell Signalling, LC40C3) was used in western blot on human samples (fig 3). J Clin Invest (2015) ncbi
domestic rabbit monoclonal (C48H11)
  • immunoprecipitation; human
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, 2569) was used in immunoprecipitation on human samples . Nucleic Acids Res (2014) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; fig 1
Cell Signaling Technology TCF7L2 antibody (Cell Signaling Technology, 2569) was used in western blot on human samples (fig 1). Carcinogenesis (2014) ncbi
domestic rabbit monoclonal (C48H11)
  • western blot; human; 1:1000
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, C48H11) was used in western blot on human samples at 1:1000. BMC Cell Biol (2013) ncbi
domestic rabbit monoclonal (C48H11)
  • chromatin immunoprecipitation; mouse
Cell Signaling Technology TCF7L2 antibody (Cell Signaling, 2569) was used in chromatin immunoprecipitation on mouse samples . J Biol Chem (2013) ncbi
domestic rabbit monoclonal (C9B9)
  • western blot; mouse; 1:1000
Cell Signaling Technology TCF7L2 antibody (Cell Signalling, C9B9) was used in western blot on mouse samples at 1:1000. Nucleic Acids Res (2012) ncbi
Articles Reviewed
  1. Talley M, Nardini D, Shabbir N, Ehrman L, Prada C, Waclaw R. Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995 pubmed publisher
  2. Low J, Du W, Gocha T, Oguz G, Zhang X, Chen M, et al. Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction. iScience. 2021;24:102544 pubmed publisher
  3. Zewdu R, Mehrabad E, Ingram K, Fang P, Gillis K, Camolotto S, et al. An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. elife. 2021;10: pubmed publisher
  4. Du J, Yu Q, Liu Y, Du S, Huang L, Xu D, et al. A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics. 2021;11:4207-4231 pubmed publisher
  5. Cleal L, McHaffie S, Lee M, Hastie N, Martínez Estrada O, Chau Y. Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia. Dis Model Mech. 2021;14: pubmed publisher
  6. Tan Y, Sementino E, Liu Z, Cai K, Testa J. Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Sci Rep. 2020;10:15837 pubmed publisher
  7. Zhao X, Shao P, Gai K, Li F, Shan Q, Xue H. β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. elife. 2020;9: pubmed publisher
  8. Liu C, He S, Zhang J, Li S, Chen J, Han C. Silencing TCF4 Sensitizes Melanoma Cells to Vemurafenib Through Inhibiting GLUT3-Mediated Glycolysis. Onco Targets Ther. 2020;13:4905-4915 pubmed publisher
  9. Cui J, Duan J, Chu J, Guo C, Xi M, Li Y, et al. Chikusetsu saponin IVa protects pancreatic β cell against intermittent high glucose-induced injury by activating Wnt/β-catenin/TCF7L2 pathway. Aging (Albany NY). 2020;12:1591-1609 pubmed publisher
  10. Chen M, Lu P, Ma Q, Cao Y, Chen N, Li W, et al. CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes. Sci Adv. 2020;6:eaax9605 pubmed publisher
  11. Xing T, Benderman L, Sabu S, Parker J, Yang J, Lu Q, et al. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Cell Mol Gastroenterol Hepatol. 2020;9:641-659 pubmed publisher
  12. van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
  13. Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
  14. Wanet A, Caruso M, Domelevo Entfellner J, Najar M, Fattaccioli A, Demazy C, et al. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017;35:2184-2197 pubmed publisher
  15. Ku A, Shaver T, Rao A, Howard J, Rodriguez C, Miao Q, et al. TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. elife. 2017;6: pubmed publisher
  16. Mackey A, Magnan M, Chazaud B, Kjaer M. Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration. J Physiol. 2017;595:5115-5127 pubmed publisher
  17. Fry C, Johnson D, Ireland M, Noehren B. ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle. J Orthop Res. 2017;35:1876-1885 pubmed publisher
  18. de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher
  19. Liu Y, Xu Y, Guo S, Chen H. T cell factor-4 functions as a co-activator to promote NF-?B-dependent MMP-15 expression in lung carcinoma cells. Sci Rep. 2016;6:24025 pubmed publisher
  20. Rockel J, Yu C, Whetstone H, Craft A, Reilly K, Ma H, et al. Hedgehog inhibits ?-catenin activity in synovial joint development and osteoarthritis. J Clin Invest. 2016;126:1649-63 pubmed publisher
  21. Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, et al. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nat Commun. 2016;7:10883 pubmed publisher
  22. Cironi L, Petricevic T, Fernandes Vieira V, Provero P, Fusco C, Cornaz S, et al. The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma. Sci Rep. 2016;6:22113 pubmed publisher
  23. Mikhailova A, Ilmarinen T, Ratnayake A, Petrovski G, Uusitalo H, Skottman H, et al. Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction. Exp Eye Res. 2016;146:26-34 pubmed publisher
  24. Eisses J, Criscimanna A, Dionise Z, Orabi A, Javed T, Sarwar S, et al. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185:3304-15 pubmed publisher
  25. Mikhailova A, Jylhä A, Rieck J, Nättinen J, Ilmarinen T, Veréb Z, et al. Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells. Sci Rep. 2015;5:14684 pubmed publisher
  26. Ma B, Fey M, Hottiger M. WNT/β-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-κB target genes. J Cell Sci. 2015;128:2430-6 pubmed publisher
  27. Plessl K, Haider S, Fiala C, Pollheimer J, Knöfler M. Expression pattern and function of Notch2 in different subtypes of first trimester cytotrophoblast. Placenta. 2015;36:365-71 pubmed publisher
  28. Walker M, Stopford C, Cederlund M, Fang F, Jahn C, Rabinowitz A, et al. FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Sci Signal. 2015;8:ra12 pubmed publisher
  29. Menon M, Chuang P, Li Z, Wei C, Zhang W, Luan Y, et al. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. J Clin Invest. 2015;125:208-21 pubmed publisher
  30. Norton L, Chen X, Fourcaudot M, Acharya N, DeFronzo R, Heikkinen S. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Res. 2014;42:13646-61 pubmed publisher
  31. Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
  32. Ogunkolade B, Jones T, Aarum J, Szary J, Owen N, Ottaviani D, et al. BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol. 2013;14:52 pubmed publisher
  33. Nakamura I, Fernández Barrena M, Ortiz Ruiz M, Almada L, Hu C, Elsawa S, et al. Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J Biol Chem. 2013;288:21389-98 pubmed publisher
  34. Wallmen B, Schrempp M, Hecht A. Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/?-catenin target gene expression. Nucleic Acids Res. 2012;40:9455-69 pubmed publisher